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Article: Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Gantz SC; Ford CP; Neve KA; Williams JT J. Neurosci., 2011
Binding densities and affinities of [3H]YM-09151-2 in midbrain and striatum do not differ between age-matched wild-type and Mecp2+/− females
| Region | Age | Kd (pm) | Bmax (fmol/mg protein) | n | |||
|---|---|---|---|---|---|---|---|
| Mecp2+/+ | Mecp2+/− | Mecp2+/+ | Mecp2+/− | Mecp2+/+ | Mecp2+/− | ||
| Midbrain | Young (26–37 d) | 18 (16–20) | 29 (19–44) | 58.2 ± 6.9 | 58.8 ± 10.0 | 7 | 3 |
| Adult (169–446 d) | 24 (23–26) | 23 (19–27) | 44.7 ± 2.0 | 43.8 ± 4.6 | 7 | 6 | |
| Striatum | Young (26–37 d) | 16 (13–19) | 18 (13–25) | 709.7 ± 48.9 | 737.9 ± 12.8 | 4 | 3 |
| Adult (169–446 d) | 17 (15–19) | 17 (15–20) | 569.6 ± 17.9° | 591.6 ± 45.2° | 7 | 6 | |
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The affinity (Kd) and density (Bmax) of D2 receptors were determined by saturation analysis of binding of [3H]YM-09151-2 in membranes prepared from three to seven brains as described under Materials and Methods. Kd values are the geometric means, followed by the limits defined by the SEM in parentheses. Bmax values represent the mean ± SEM; the symbol ° designates statistical significance compared to young age within genotype. Boldface designates statistical significance.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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