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Article: Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids.

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André VM; Cepeda C; Cummings DM; Jocoy EL; Fisher YE; William Yang X; Levine MS
Eur. J. Neurosci., 2010


Table 1.   Acutely isolated and slice neuron membrane properties
 Soma (μm2)Cm (pF)RmTau (ms)

  1. Values are presented as means ± SEM. Cm, capacitance; Rm, input resistance; tau, time constant. *P < 0.01, **P < 0.001, ***P < 0.05 (t-test). D1 cell, D1 receptor-expressing medium-sized spiny neuron; D2 cell, D2 receptor-expressing medium-sized spiny neuron.

Acutely isolated neurons
 D1 cells (n = 64)94.6 ± 2.713.4 ± 0.31.7 ± 0.1 GΩ155 ± 8
 D2 cells (n = 89)83.4 ± 2.4*12.2 ± 0.2**2.1 ± 0.1 GΩ***129 ± 5*
Slice neurons
 D1 cells (n = 79)–92.6 ± 2.476 ± 6 MΩ2.6 ± 0.1
 D2 cells (n = 69)–85.8 ± 2.1***133 ± 12 MΩ**2.2 ± 0.1*

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D1 receptor-expressing neuron cell capacitance (pF) 92.6 ± 2.4 (79) 92.6 (pF) Data Table
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D1 receptor-expressing neuron input resistance 76.0 ± 6.0 (79) 76.0 (MΩ) Data Table
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D1 receptor-expressing neuron membrane time constant (ms) 2.6 ± 0.1 (79) 2.6 (ms) Data Table
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D2 receptor-expressing neuron cell capacitance (pF) 85.8 ± 2.1 (69) 85.8 (pF) Data Table
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D2 receptor-expressing neuron input resistance 133.0 ± 12.0 (69) 133.0 (MΩ) Data Table
Neostriatum medium spiny neuron dorsal striatum medium-sized spiny D2 receptor-expressing neuron membrane time constant (ms) 2.2 ± 0.1 (69) 2.2 (ms) Data Table