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Article: A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Tricoire L; Pelkey KA; Erkkila BE; Jeffries BW; Yuan X; McBain CJ J. Neurosci., 2011
Table 3.
Electrophysiological properties of the different identified interneuron clusters
| Cluster 1 (n = 15) | Cluster 2 (n = 23) | Cluster 3 (n = 34) | Cluster 4 (n = 33) | Cluster 5 (n = 19) | Cluster 6 (n = 18) | Comparison | |
|---|---|---|---|---|---|---|---|
| Resting potential (mV) | −57 ± 5 | −64 ± 7 | −70 ± 10 | −57 ± 10 | −59 ± 10 | −54 ± 6 | 3<<1,2,4,5,6 |
| Input resistance (MΩ) | 116 ± 63 | 216 ± 124 | 302 ± 139 | 431 ± 193 | 401 ± 212 | 219 ± 98 | 1<<2,3,4,5,6, |
| Time constant (ms) | 13 ± 8 | 46 ± 18 | 25 ± 8 | 44 ± 15 | 38 ± 13 | 22 ± 9 | 1<<3,6<<<2,4,5 |
| Sag index | 0.84 ± 0.06 | 0.79 ± 0.09 | 0.88 ± 0.06 | 0.80 ± 0.10 | 0.80 ± 0.07 | 0.71 ± 0.15 | 1,2,4,5,6<3 |
| Frequency at 2× threshold (Hz) | 70 ± 26 | 19 ± 9 | 27 ± 10 | 17 ± 7 | 18 ± 6 | 27 ± 13 | 2,4,5<<3,6<<<1 |
| Adaptation ratio at 2× threshold | 0.88 ± 0.13 | 0.64 ± 0.22 | 0.80 ± 0.12 | 0.56 ± 0.17 | 0.44 ± 0.17 | 0.46 ± 0.17 | 4,5,6<2<<<3<1 |
| First spike threshold (mV) | −32 ± 4 | −38 ± 3 | −34 ± 4 | −35 ± 3 | −36 ± 3 | −38 ± 4 | 2,4,5,6<3,1 |
| Second spike threshold (mV) | −32 ± 4 | −37 ± 3 | −34 ± 4 | −35 ± 3 | −35 ± 4 | −37 ± 4 | 1,2,3,4,5,6 |
| First spike amplitude (mV) | 47 ± 7 | 62 ± 8 | 52 ± 9 | 62 ± 6 | 48 ± 10 | 59 ± 8 | 1,3,5<2,4,6 |
| Second spike amplitude (mV) | 48 ± 8 | 61 ± 7 | 52 ± 9 | 61 ± 6 | 48 ± 10 | 60 ± 7 | 1,5<3<<2,4,6 |
| First spike half-width (ms) | 0.54 ± 0.11 | 0.74 ± 0.11 | 1.06 ± 0.20 | 0.81 ± 0.09 | 1.04 ± 0.15 | 0.72 ± 0.10 | 1<<<2,6<<4<<<3,5 |
| Second Spike half-width (ms) | 0.54 ± 0.11 | 0.77 ± 0.12 | 1.08 ± 0.21 | 0.86 ± 0.10 | 1.12 ± 0.14 | 0.77 ± 0.10 | 1<<<2,6<<4<<<3,5 |
| First time to repolarize (ms) | 3.1 ± 1.2 | 4.3 ± 1.6 | 9.6 ± 4.1 | 10.8 ± 7.8 | 20.4 ± 12.7 | 11.5 ± 6.8 | 1<2<<<3,4,6< 5 |
| Second time to repolarize (ms) | 3.1 ± 1.1 | 4.7 ± 1.5 | 9.9 ± 3.7 | 13.1 ± 7.7 | 23.2 ± 10.1 | 16.3 ± 10.0 | 1<<2<<<3,4,6<<5 |
| First maximal decay slope (mV/ms) | −112 ± 24 | −96 ± 17 | −55 ± 13 | −79 ± 16 | −50 ± 12 | −83 ± 14 | 1<2<4,6<<<3,5 |
| Second maximal decay slope (mV/ms) | −113 ± 26 | −91 ± 18 | −55 ± 13 | −74 ± 15 | −46 ± 10 | −78 ± 14 | 1<<2<<4,6<<<3<<5 |
| First AHP amplitude (mV) | 25 ± 3 | 21 ± 3 | 20 ± 3 | 19 ± 3 | 13 ± 3 | 14 ± 3 | 5,6<<<4<<2,3<<1 |
| Second AHP amplitude (mV) | 25 ± 4 | 22 ± 3 | 21 ± 4 | 20 ± 4 | 15 ± 4 | 15 ± 3 | 5,6<<<2,3,4<<1 |
| First AHP half-width (ms) | 29 ± 16 | 55 ± 36 | 72 ± 31 | 124 ± 76 | 85 ± 41 | 63 ± 31 | 1<2,3,4,5,6 |
| Second AHP half-width (ms) | 27 ± 15 | 76 ± 47 | 69 ± 33 | 129 ± 50 | 116 ± 63 | 82 ± 32 | 1<<<2,3,6<4,5 |
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n, Number of cells.
-
< indicates significantly smaller with p ≤ 0.05.
-
<< indicates significantly smaller with p ≤ 0.01.
-
<<< indicates significantly smaller with p ≤ 0.001.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | resting membrane potential (mV) | -57.0 ± 5.0 (15) | -57.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | resting membrane potential (mV) | -64.0 ± 7.0 (23) | -64.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | resting membrane potential (mV) | -70.0 ± 10.0 (34) | -70.0 (mV) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | resting membrane potential (mV) | -57.0 ± 10.0 (33) | -57.0 (mV) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | resting membrane potential (mV) | -59.0 ± 10.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | resting membrane potential (mV) | -54.0 ± 6.0 (18) | -54.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | input resistance (MΩ) | 116.0 ± 63.0 (15) | 116.0 (MΩ) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | input resistance (MΩ) | 216.0 ± 124.0 (23) | 216.0 (MΩ) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | input resistance (MΩ) | 302.0 ± 139.0 (34) | 302.0 (MΩ) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | input resistance (MΩ) | 431.0 ± 193.0 (33) | 431.0 (MΩ) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | input resistance (MΩ) | 401.0 ± 212.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | input resistance (MΩ) | 219.0 ± 98.0 (18) | 219.0 (MΩ) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | membrane time constant (ms) | 13.0 ± 8.0 (15) | 13.0 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | membrane time constant (ms) | 46.0 ± 18.0 (23) | 46.0 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | membrane time constant (ms) | 25.0 ± 8.0 (34) | 25.0 (ms) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | membrane time constant (ms) | 44.0 ± 15.0 (33) | 44.0 (ms) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | membrane time constant (ms) | 38.0 ± 13.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | membrane time constant (ms) | 22.0 ± 9.0 (18) | 22.0 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | sag ratio | 0.84 ± 0.06 (15) | 0.84 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | sag ratio | 0.79 ± 0.09 (23) | 0.79 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | sag ratio | 0.88 ± 0.06 (34) | 0.88 (ratio) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | sag ratio | 0.8 ± 0.1 (33) | 0.8 (ratio) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | sag ratio | 0.8 ± 0.07 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | sag ratio | 0.71 ± 0.15 (18) | 0.71 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | adaptation ratio (at) | 0.88 ± 0.13 (15) | 0.88 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | adaptation ratio (at) | 0.64 ± 0.22 (23) | 0.64 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | adaptation ratio (at) | 0.8 ± 0.12 (34) | 0.8 (ratio) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | adaptation ratio (at) | 0.56 ± 0.17 (33) | 0.56 (ratio) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | adaptation ratio (at) | 0.44 ± 0.17 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | adaptation ratio (at) | 0.46 ± 0.17 (18) | 0.46 (ratio) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | spike threshold (mV) | -32.0 ± 4.0 (15) | -32.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | spike threshold (mV) | -38.0 ± 3.0 (23) | -38.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | spike threshold (mV) | -34.0 ± 4.0 (34) | -34.0 (mV) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | spike threshold (mV) | -35.0 ± 3.0 (33) | -35.0 (mV) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | spike threshold (mV) | -36.0 ± 3.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | spike threshold (mV) | -38.0 ± 4.0 (18) | -38.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | spike amplitude (mV) | 47.0 ± 7.0 (15) | 47.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | spike amplitude (mV) | 62.0 ± 8.0 (23) | 62.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | spike amplitude (mV) | 52.0 ± 9.0 (34) | 52.0 (mV) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | spike amplitude (mV) | 62.0 ± 6.0 (33) | 62.0 (mV) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | spike amplitude (mV) | 48.0 ± 10.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | spike amplitude (mV) | 59.0 ± 8.0 (18) | 59.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | spike half-width (ms) | 0.54 ± 0.11 (15) | 0.54 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | spike half-width (ms) | 0.74 ± 0.11 (23) | 0.74 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | spike half-width (ms) | 1.06 ± 0.2 (34) | 1.06 (ms) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | spike half-width (ms) | 0.81 ± 0.09 (33) | 0.81 (ms) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | spike half-width (ms) | 1.04 ± 0.15 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | spike half-width (ms) | 0.72 ± 0.1 (18) | 0.72 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | spike decay time (ms) | 3.1 ± 1.2 (15) | 3.1 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | spike decay time (ms) | 4.3 ± 1.6 (23) | 4.3 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | spike decay time (ms) | 9.6 ± 4.1 (34) | 9.6 (ms) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | spike decay time (ms) | 10.8 ± 7.8 (33) | -- | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | spike decay time (ms) | 20.4 ± 12.7 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | spike decay time (ms) | 11.5 ± 6.8 (18) | -- | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | spike max decay slope (mV/ms) | -112.0 ± 24.0 (15) | 112.0 (mV/ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | spike max decay slope (mV/ms) | -96.0 ± 17.0 (23) | 96.0 (mV/ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | spike max decay slope (mV/ms) | -55.0 ± 13.0 (34) | 55.0 (mV/ms) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | spike max decay slope (mV/ms) | -79.0 ± 16.0 (33) | 79.0 (mV/ms) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | spike max decay slope (mV/ms) | -50.0 ± 12.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | spike max decay slope (mV/ms) | -83.0 ± 14.0 (18) | 83.0 (mV/ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | AHP amplitude (mV) | 25.0 ± 3.0 (15) | 25.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | AHP amplitude (mV) | 21.0 ± 3.0 (23) | 21.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | AHP amplitude (mV) | 20.0 ± 3.0 (34) | 20.0 (mV) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | AHP amplitude (mV) | 19.0 ± 3.0 (33) | 19.0 (mV) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | AHP amplitude (mV) | 13.0 ± 3.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | AHP amplitude (mV) | 14.0 ± 3.0 (18) | 14.0 (mV) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, paravalbumin-expressing, fast-spiking, basket, bistratified, and axo-axonic cells | AHP duration (ms) | 29.0 ± 16.0 (15) | 29.0 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE-derived, somatostatin expressing cells | AHP duration (ms) | 55.0 ± 36.0 (23) | 55.0 (ms) | Data Table |
| Hippocampus CA1 basket cell | Hippocampal MGE and CGE derived, late-spiking, NPY expressing cells | AHP duration (ms) | 72.0 ± 31.0 (34) | 72.0 (ms) | Data Table |
| Other | resembled hippocampal Schaffer collateral associated cells and hippocampal associational commissural-associated cells | AHP duration (ms) | 124.0 ± 76.0 (33) | 124.0 (ms) | Data Table |
| Other | hippocampal GABAergic projection cells or interneuron-targeting interneurons | AHP duration (ms) | 85.0 ± 41.0 (19) | -- | Data Table |
| Hippocampus CA1 basket cell | hippocampal CCK, VGluT3 and VIP expressing basket cells | AHP duration (ms) | 63.0 ± 31.0 (18) | 63.0 (ms) | Data Table |