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Article: Postnatal development of intrinsic and synaptic properties transforms signaling in the layer 5 excitatory neural network of the visual cortex.

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Etherington SJ; Williams SR
J. Neurosci., 2011


Table 1.

Postnatal maturation of action potential properties

Property Age (days postnatal)
P11 P15 P25–P29
AP threshold (mV) −39.5 ± 0.94 (5) −44.8 ± 0.95 (9)* −45.4 ± 0.77 (19)*
Relative AP threshold (mV above Vm) 24.0 ± 0.81 (5) 21.7 ± 1.4 (9) 24.1 ± 1.0 (19)
AP amplitude (mV above threshold) 75.7 ± 3.0 (5) 82.1 ± 1.8 (9) 84.8 ± 1.4 (19)*
AP rise time 10–90% (ms) 0.246 ± 0.014 (5) 0.214 ± 0.0083 (9) 0.194 ± 0.0065 (19)**
AP half-width (ms) 1.18 ± 0.082 (5) 0.786 ± 0.020 (9) 0.680 ± 0.020 (19)***,#
Peak AP derivative (Vs − 1) 314 ± 29 (5) 419 ± 27 (9) 475 ± 17 (21)**
Slow AHP amplitude (mV) −13.0 ± 0.83 (5) −8.74 ± 1.5 (9)** −8.91 ± 0.46 (17)*

  • All results are shown as mean ± SEM (n). Significance was determined by nonparametric Kruskal–Wallis test followed by Dunn's multiple comparison post-tests. Overall differences were statistically significant (p < 0.05) for all variables except for relative AP threshold (p = 0.374). Action potential and afterhyperpolarizing potential (AHP) amplitudes are expressed relative to AP threshold (Vt).

  • ↵*p < 0.05;

  • ↵**p < 0.01;

  • ↵***p < 0.001 (significantly different from P11 level);

  • ↵#p < 0.05 (significantly different from P15 level).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike amplitude 75.7 ± 3.0 (5) 75.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike amplitude 82.1 ± 1.8 (9) 82.1 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike amplitude 84.8 ± 1.4 (19) 84.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike rise time (ms) 0.246 ± 0.014 (5) 0.246 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike rise time (ms) 0.214 ± 0.0083 (9) 0.214 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike rise time (ms) 0.194 ± 0.0065 (19) 0.194 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike half-width (ms) 1.18 ± 0.082 (5) 1.18 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike half-width (ms) 0.786 ± 0.02 (9) 0.786 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike threshold (mV) -39.5 ± 0.94 (5) -39.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike half-width (ms) 0.68 ± 0.02 (19) 0.68 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike max rise slope 314.0 ± 29.0 (5) 314.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike max rise slope 419.0 ± 27.0 (9) 419.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike max rise slope 475.0 ± 17.0 (21) 475.0 (mV/ms) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons slow AHP amplitude (mV) -13.0 ± 0.83 (5) 13.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons slow AHP amplitude (mV) -8.74 ± 1.5 (9) 8.74 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons slow AHP amplitude (mV) -8.91 ± 0.46 (17) 8.91 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike threshold (mV) -44.8 ± 0.95 (9) -44.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Visual Cortex Layer 5 large thick-tufted Pyramidal Neurons spike threshold (mV) -45.4 ± 0.77 (19) -45.4 (mV) Data Table