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Article: Neuregulin-1 signals from the periphery regulate AMPA receptor sensitivity and expression in GABAergic interneurons in developing neocortex.

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Abe Y; Namba H; Kato T; Iwakura Y; Nawa H
J. Neurosci., 2011


Table 1.

Electrophysiologic properties of fast-spiking neurons

Control (n = 20) eNRG1 (n = 20)
Series resistance (MΩ) 16.0 ± 0.8 15.6 ± 0.8
Input resistance (MΩ) 258 ± 23 274 ± 20
Capacitance (pF) 115 ± 7 113 ± 4
AHP amplitude (mV) −22.4 ± 0.9 −20.5 ± 0.6
Voltage sag (mV) −8.7 ± 1.8 −8.8 ± 1.1
Resting potential (mV) −59.1 ± 1.0 −56.5 ± 1.3
AP frequency (Hz) 78.1 ± 2.4 78.7 ± 2.4
  • Input resistance and series resistance were determined by measuring the current response to a −5 mV pulse from the holding potential. Cell capacitance measurements were made by integrating capacitive transients. Afterhyperpolarization (AHP) was determined after the first action potential (AP) triggered by the minimum depolarizing current (100–300 pA). Voltage sag was determined by measuring voltage responses to a hyperpolarizing current (−400 pA, 450 ms). Action potentials were generated by current injection (800 pA, 450 ms), and their frequency was measured. No statistical differences were detected in these electrophysiologic properties.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell frontal cortex fast spiking neuron AHP amplitude (mV) -22.4 ± 0.9 (20) 22.4 (mV) Data Table
Neocortex basket cell frontal cortex fast spiking neuron sag amplitude (mV) -8.7 ± 1.8 (20) -8.7 (mV) Data Table
Neocortex basket cell frontal cortex fast spiking neuron resting membrane potential (mV) -59.1 ± 1.0 (20) -59.1 (mV) Data Table
Neocortex basket cell frontal cortex fast spiking neuron access resistance (MΩ) 16.0 ± 0.8 (20) 16.0 (MΩ) Data Table
Neocortex basket cell frontal cortex fast spiking neuron firing frequency (Hz) 78.1 ± 2.4 (20) 78.1 (Hz) Data Table
Neocortex basket cell frontal cortex fast spiking neuron input resistance (MΩ) 258.0 ± 23.0 (20) 258.0 (MΩ) Data Table
Neocortex basket cell frontal cortex fast spiking neuron cell capacitance (pF) 115.0 ± 7.0 (20) 115.0 (pF) Data Table