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Article: Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury.

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Gemes G; Bangaru ML; Wu HE; Tang Q; Weihrauch D; Koopmeiners AS; Cruikshank JM; Kwok WM; Hogan QH
J. Neurosci., 2011


Table 1.

Electrophysiological behavior of control and injured fifth lumbar dorsal root ganglion neurons during either blockade of store-operated Ca2+ entry with TRIM (200 μm) or application of vehicle (DMSO, 0.2%)

Injury group/treatment group ANOVA main effects
Control Spinal nerve ligation
DMSO (n = 23) TRIM (n = 19) DMSO (n = 46) TRIM (n = 57) Injury Treatment
Diameter (μm) 30 ± 1 28 ± 1 30 ± 1 31 ± 1 NS NS
RMP (mV) −53.3 ± 1.9 −52.4 ± 1.9 −54.0 ± 1.0 −55.1 ± 1.1 NS NS
Rin (MΩ) 63.1 ± 6.0 58.9 ± 10.3 99.0 ± 11.5 56.4 ± 7.3* NS 0.002
AP duration (ms) 1.4 ± 0.2 1.2 ± 0.2 2.3 ± 0.2† 2.2 ± 0.2† <0.001 NS
AHP amplitude (mV) 18.2 ± 1.1 20.0 ± 1.7 10.0 ± 0.9† 12.2 ± 0.8† <0.001 0.045
AHP duration (ms) 3.6 ± 0.5 3.0 ± 0.4 4.5 ± 0.5 3.4 ± 0.2 NS 0.020
Rheobase (nA) 1.36 ± 0.15 2.37 ± 0.38* 0.78 ± 0.07 1.11 ± 0.08† <0.001 0.001
AP threshold (mV) −12.9 ± 3.4 −12.8 ± 3.2 −19.8 ± 2.2 −30.6 ± 2.0†* <0.001 0.004
Repetitive firing (%) 26 59* 30 51* NA NA

  • RMP, Resting membrane potential; Rin, input resistance; AP duration, action potential width measured at 50% amplitude; AHP duration, width measured at 80% of afterhyperpolarization amplitude; rheobase, the minimum depolarizing current adequate to produce an AP; AP threshold, the minimal depolarization voltage adequate to produce an AP; repetitive firing, generation of >1 AP during depolarization to voltages <30 mV. Numbers are average ± SEM. n, Number of neurons; NA, not applicable; NA, not significant (p > 0.05).

  • ↵*Different from DMSO in that injury group, by paired comparisons using Tukey's honest significant difference, except for repetitive firing (t test), p < 0.05.

  • ↵†Different from control in that treatment group.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -52.4 ± 1.9 -52.4 (mV) Data Table
Dorsal root ganglion cell input resistance (MΩ) 63.1 ± 6.0 63.1 (MΩ) Data Table
Dorsal root ganglion cell input resistance (MΩ) 58.9 ± 10.3 58.9 (MΩ) Data Table
Dorsal root ganglion cell cell diameter 30.0 ± 1.0 30.0 (um) Data Table
Dorsal root ganglion cell spike half-width (ms) 1.4 ± 0.2 1.4 (ms) Data Table
Dorsal root ganglion cell spike half-width (ms) 1.2 ± 0.2 1.2 (ms) Data Table
Dorsal root ganglion cell cell diameter 28.0 ± 1.0 28.0 (um) Data Table
Dorsal root ganglion cell AHP amplitude (mV) 18.2 ± 1.1 18.2 (mV) Data Table
Dorsal root ganglion cell AHP amplitude (mV) 20.0 ± 1.7 20.0 (mV) Data Table
Dorsal root ganglion cell AHP duration (ms) 3.6 ± 0.5 3.6 (ms) Data Table
Dorsal root ganglion cell AHP duration (ms) 3.0 ± 0.4 3.0 (ms) Data Table
Dorsal root ganglion cell rheobase (nA) 1.36 ± 0.15 1360.0 (pA) Data Table
Dorsal root ganglion cell rheobase (nA) 2.37 ± 0.38 2370.0 (pA) Data Table
Dorsal root ganglion cell spike threshold (mV) -12.9 ± 3.4 -12.9 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -12.8 ± 3.2 -12.8 (mV) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -53.3 ± 1.9 -53.3 (mV) Data Table