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Article: Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.

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Dvorzhak A; Semtner M; Faber DS; Grantyn R
J. Physiol. (Lond.), 2013

Table 1.  Comparison of membrane properties and network activity in R6/2 WT and CAR mice
PropertyWTCAR p valueTest
Mean±SEM n Mean±SEM n
  1. All measurements at a holding voltage Vh=−70 mV and chloride reversal potential ECl=−21 mV. The age of the R6/2 cohort was 78.0 ± 1.1 days, n= 91 vs. CAR 75.0 ± 1.2 days, n= 77 (n.s.). Abbreviations: n, number of neurons; p value, significance level; for all other abbreviations see list on Introduction page.

Membrane potential (mV)−69.50.58108−60.50.96101<0.0001Mann-Whitney’s U test
Whole-cell input resistance (MΩ)
 Intracellular standard59.22.50107128.28.4499<0.0001Mann-Whitney’s U test
 Intracellular with GDPβS38.13.101372.704.8037<0.0010Student's unpaired t test
Whole-cell capacitance (pF)79.71.9110766.11.6399<0.0001Student's unpaired t test
Reobasic current (pA)189.611.667197.36.1466<0.0001Mann-Whitney’s U test

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neostriatum medium spiny neuron input resistance 59.2 59.2 (MΩ) Data Table
Neostriatum medium spiny neuron resting membrane potential (mV) -69.5 -69.5 (mV) Data Table
Neostriatum medium spiny neuron cell capacitance (pF) 79.7 79.7 (pF) Data Table
Neostriatum medium spiny neuron rheobase (pA) 189.6 189.6 (pA) Data Table