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Article: Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Bedi SS; Yang Q; Crook RJ; Du J; Wu Z; Fishman HM; Grill RJ; Carlton SM; Walters ET
J. Neurosci., 2010


Table 2.

Electrophysiological properties of small dissociated DRG neurons lacking SA

Property Naive Sham SCI SCI vs sham SCI vs naive Sham vs naive
Soma diameter (μm) 23.1 ± 0.4 (22, 106) 22.8 ± 0.3 (24, 126) 22.9 ± 0.4 (22, 96) NS NS NS
RMP (mV) −50.9 ± 0.6 (22, 106) −50.8 ± 0.6 (24, 128) −52.4 ± 0.6 (23, 96) NS NS NS
Rheobase (400 ms pulse, pA) 64.0 ± 7.1 (22, 94) 60.2 ± 5.6 (24, 112) 64.3 ± 6.0 (22, 86) NS NS NS
AP threshold at −50 mV (2 ms pulse, pA) 383 ± 21 (21, 96) 378 ± 19 (24, 121) 367 ± 25 (22, 81) NS NS NS
AP threshold at −80 mV (2 ms pulse, pA) 763 ± 27 (21, 95) 785 ± 25 (24, 122) 705 ± 32 (22, 81) NS p < 0.05 NS
Repetitive firing (spike number, 400 ms) 2.8 ± 0.2 (22, 102) 2.8 ± 0.3 (24, 122) 2.9 ± 0.2 (23, 94) NS NS NS
Rm (MΩ) 534 ± 28 (21, 99) 541 ± 28 (24, 121) 592 ± 38 (22, 95) NS NS NS
  • Data are from silent neurons (no SA) sampled from DRGs at all time points and all spinal levels from male and female animals.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell cell diameter (μm) 23.1 ± 0.4 23.1 (um) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -50.9 ± 0.6 -50.9 (mV) Data Table
Dorsal root ganglion cell rheobase 64.0 ± 7.1 -- Data Table
Dorsal root ganglion cell spike threshold 383.0 ± 21.0 -- Data Table
Dorsal root ganglion cell spike threshold 763.0 ± 27.0 -- Data Table