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Article: BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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Hu X; Zhou X; He W; Yang J; Xiong W; Wong P; Wilson CG; Yan R
J. Neurosci., 2010


Table 3.

Increased susceptibility of BACE1-null mice to kainic acid-induced seizures

Genotype Behavior
Response stage
0 1 2 3 4 5 6
No. of BACE1+/+ mice 0 0 1 1 1 4 4
No. of BACE1−/− mice 0 0 0 0 1 2 8
  • Kainic acid (15 mg/kg) was injected intraperitoneally in 4-month-old wild-type (n = 11) and BACE1-null mice (n = 11). Scoring of kainic acid-induced seizures is based on the following criteria: 0, no response; 1, freezing, staring, mouth or facial movements; 2, rigid posture, head nodding, or isolated twitches; 3, tail extension, unilateral-bilateral forelimb clonus, or repetitive scratching; 4, rearing with one or both forepaws extended; 5, clonic seizures with loss of posture, jumping, and falling; 6, severe tonic seizures.


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