Article: BACE1 deficiency causes altered neuronal activity and neurodegeneration.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Hu X; Zhou X; He W; Yang J; Xiong W; Wong P; Wilson CG; Yan R J. Neurosci., 2010
Genotype | Behavior | ||||||
---|---|---|---|---|---|---|---|
Response stage | |||||||
0 | 1 | 2 | 3 | 4 | 5 | 6 | |
No. of BACE1+/+ mice | 0 | 0 | 1 | 1 | 1 | 4 | 4 |
No. of BACE1â/â mice | 0 | 0 | 0 | 0 | 1 | 2 | 8 |
-
Kainic acid (15 mg/kg) was injected intraperitoneally in 4-month-old wild-type (n = 11) and BACE1-null mice (n = 11). Scoring of kainic acid-induced seizures is based on the following criteria: 0, no response; 1, freezing, staring, mouth or facial movements; 2, rigid posture, head nodding, or isolated twitches; 3, tail extension, unilateral-bilateral forelimb clonus, or repetitive scratching; 4, rearing with one or both forepaws extended; 5, clonic seizures with loss of posture, jumping, and falling; 6, severe tonic seizures.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|