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Article: BACE1 deficiency causes altered neuronal activity and neurodegeneration.

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Hu X; Zhou X; He W; Yang J; Xiong W; Wong P; Wilson CG; Yan R
J. Neurosci., 2010


Table 4.

Action potential parameters from hippocampal pyramidal neurons

Threshold (mV) Amplitude (mV) Max dV/dt (mV/ms) AP min (mV) Half-width (ms) Input resistance (MΩ)
BACE1+/+ −44.1 ± 1.2 90.3 ± 2.4 86.3 ± 2.3 −54.6 ± 2.7 2.36 ± 0.34 400 ± 57
BACE1−/− −45.2 ± 1.4 101.4 ± 3.3* 94.7 ± 2.6* −56.3 ± 2.0 2.63 ± 0.39 450 ± 65

  • ↵*p < 0.05, Student's t test, significantly different from BACE1+/+.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike threshold (mV) -44.1 ± 1.2 (11) -44.1 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 90.3 ± 2.4 (11) 90.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope (mV/ms) 86.3 ± 2.3 (11) 86.3 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell other (mV) -54.6 ± 2.7 (11) -- Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 2.36 ± 0.34 (11) 2.36 (ms) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 400.0 ± 57.0 (11) 400.0 (MΩ) Data Table