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Article: Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons.

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Elbasiouny SM; Amendola J; Durand J; Heckman CJ
J. Neurosci., 2010

Table 3.

Properties of MN 3 mSOD1-like model compared to experimental data

Property No Ih current Ih current Experimental dataa Mean (confidence interval)
morph morph + Rm morph morph + Rm
Rin 92% 66% 85% 68% 70% (63–78%)
τ0 141% 108% 118% 99% 130% (88–172%)
τ1 126% 124% 93% 111% 117%b (84–149%)
Ct 153% 163% 140% 145% 193% (86–301%)
L 93% 111% 88% 106% 100%b (84–116%)
Vrest 100% 100% 100% 100% 99% (96–103%)
Rm 100% 70% 100% 60% n/a
  • amSOD1 experimental data are presented as percentage of the mean value of the WT measurements. Experimental data of mSOD1 motoneuron electrical properties (Table 1, Fig. 1B, right). The second column (morph) illustrates the percentage change in model properties, relative to WT, when the dendritic morphology was altered and other model parameters were unchanged. The third column (morph + Rm) illustrates the percentage change in the same properties when reduction in Rm was incorporated with the altered morphology. No Ih current was included in these simulations. Fourth and fifth columns, same conditions as the second and third columns, but Ih current was included in the mSOD1-like (morph) and (morph + Rm) models. n/a, not applicable.

  • bData from Bories et al. (2007).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source