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Article: Changes in membrane excitability and potassium currents in sensitized dorsal horn neurons of mice pups.

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Rivera-Arconada I; Lopez-Garcia JA
J. Neurosci., 2010


Table 2.

Characterization of sustained (IDR) and transient (IA) currents under different experimental conditions

Control Carrageenan-treated 20 h NMDA-treated Carrageenan-treated 1 h
Basic electrophysiological properties
    n 21 8 14 11
    RMP (mV) −55.7 ± 1.5 −54.2 ± 2.2 −54.3 ± 1.3 −55.4 ± 2.2
    Rin (MΩ) 445 ± 42 486 ± 38 360 ± 34 439 ± 61
    Capacitance (pF) 19.5 ± 1.8 16.5 ± 2.0 17.4 ± 2.5 15.6 ± 2.6
Sustained currents
    n 21 8 14 11
    Max. current density (pA/pF) 25.7 ± 4.1 48.2 ± 8.8* 78.0 ± 13.9** 55.2 ± 18.6
    Max. voltage attained (mV) 21 19 21 23
    Slope activation 0.6 ± 0.1 1.2 ± 0.2* 1.7 ± 0.3** 1.1 ± 0.4
    V50 (mV) 2.1 ± 1.1 2.6 ± 1.4 0.4 ± 1.6 −9.2 ± 1.2***
    K 15.1 ± 0.5 10.7 ± 0.6*** 13.5 ± 0.6 12.1 ± 0.4***
Transient currents
    n 18 8 11 7
    Max. current density (pA/pF) 15.3 ± 3.3 18.4 ± 2.9 39.0 ± 13.1* 18.7 ± 9.3
    Max. voltage attained (mV) 8 10 10 8
    V50 (mV) −10.7 ± 2.9 −15.6 ± 2.7 −14.4 ± 1.1 −8.1 ± 7.3
    K 11.9 ± 1.8 10.8 ± 2.0 8.3 ± 1.2* 12.0 ± 1.7
Time constant (ms) 15.9 ± 1.5 15.7 ± 2.1 15.5 ± 2.5 27.2 ± 9.3
    Activation
        V50 (mV) −22.1 ± 1.8 −24.2 ± 2.7 −20.4 ± 1.2 −22.0 ± 3.6
        K 9.3 ± 0.9 8.7 ± 1.5 7.1 ± 1.1 8.5 ± 0.7
    Inactivation
        V50 (mV) −43.9 ± 1.7 −39.4 ± 2.8 −47.0 ± 2.0 −54.3 ± 4.9
        K −10.5 ± 1.0 −12.6 ± 1.6 −9.7 ± 1.2 −15.5 ± 1.9*

  • ↵Values are means ± SEM. Values for maximum (Max.) current density were obtained at the maximum voltage attained as indicated. Density of sustained currents for voltages over −18 mV were fitted to a straight line and slope values are given. For data fitted to the Boltzmann sigmoidal function, V50, voltage of half-maximal activation or inactivation, and K, slope factor. The inactivation time constant was obtained fitting isolated transient currents obtained at ≈+10 mV to a single exponential function. Asterisks stand for statistical significance using Mann–Whitney test. Levels of confidence are as follows: *p < 0.05,

  • ↵**p < 0.01,

  • ↵*** p < 0.001. n, Number of neurons; RMP, resting membrane potential; Rin, input resistance.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -55.7 ± 1.5 -55.7 (mV) Data Table
Dorsal root ganglion cell input resistance (MΩ) 445.0 ± 42.0 445.0 (MΩ) Data Table
Dorsal root ganglion cell cell capacitance (pF) 19.5 ± 1.8 19.5 (pF) Data Table
Dorsal root ganglion cell membrane time constant (ms) 15.9 ± 1.5 15.9 (ms) Data Table