Article: Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice.

Table 1.

Distribution of BDNF protein in the medulla oblongata of P35 Mecp2 wild-type mice and comparison to P35 Mecp2-null mice

Structure	P35 Mecp2 wild type		P35 Mecp2 null versus wild type
Structure	BDNF-IR cell bodies	BDNF-IR processes	BDNF-IR cell bodies	BDNF-IR processes
Intermediate reticular nucleus	−	++	−	↓↓↓
Gracile nucleus	−	+	−	↓
Lateral reticular nucleus	−	++	−	↓
Spinal trigeminal tract	−	++	−	↓
Spinal trigeminal nucleus, caudal/interpolar	+++	++	↓	↓
Inferior olive	++	+++	↓	↓↓
Nucleus tractus solitarius	+	+++	↓	↓↓↓
Motor nucleus of the glossopharyngeal nerve	−	+	−	↓
Motor nucleus of the vagus nerve	−	++++	−	↓↓↓
Area postrema	+++	++	↓↓	↓↓↓
A1/C1	−	++	−	↓↓
Raphe obscurus	−	+	−	↓
Nucleus ambiguus	−	++	−	↓↓
Rostroventrolateral reticular nucleus	−	++	−	↓↓↓
Ventral spinocerebellar tract	−	++	−	↓
Parvocellular reticular nucleus	−	++	−	↓
Prepositus nucleus	++	+/++	↓↓	↓
Raphe magnus	−	++	−	↓
Lateral paragigantocellularis nucleus	−	++	−	↓↓
Principal sensory nucleus of the trigeminal nerve, dorsomedial	−	+++	−	↓
Principal sensory nucleus of the trigeminal nerve, ventrolateral	++	−	↓	−

For BDNF-immunoreactive (IR) cell bodies: −, no cells observed; +, occasional cells; ++, scattered cells; +++, densely packed cells. For BDNF-IR cell processes: −, no processes observed; +, low density; ++, moderate density; +++, high density; ++++, very high density. For changes in null mice compared to wild types: −, no obvious change; ↓, mild decrease; ↓↓, moderate decrease; ↓↓↓, sharp decrease. Data was collected on three wild-type and three Mecp2-null mice.

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source