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Article: Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus.

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Chee MJ; Myers MG; Price CJ; Colmers WF
J. Neurosci., 2010


Table 1.

Effect of NPY on the basal properties of VMN neurons

Property Effect of 300 nm NPY on VMN neurons
n Controla 300 nm NPYb p value
Resting membrane potentialc (mV) 147 −68.9 ± 0.6 −79.6 ± 0.6 ***
Input resistance (MΩ) 65 388.3 ± 13.0 247.2 ± 11.4 ***
Rheobase (pA) 87 35.1 ± 2.3 67.4 ± 3.9 ***
Membrane currentd (pA) 7 2.9 ± 10.8 39.3 ± 11.0 **

  • All values are reported as the mean ± SEM.

  • ↵aOnly the control values of NPY-sensitive VMN neurons were reported here.

  • ↵bAll effects of NPY were fully reversed upon washout.

  • ↵cMore than 250 NPY-sensitive VMN neurons have been identified throughout this study. This data set reflects the effect of NPY on untreated VMN neurons only.

  • ↵dSteady-state membrane current was determined at a membrane potential of −75 mV in the presence of 500 nm tetrodotoxin.

  • All statistical comparisons were made by the repeated-measures one-way ANOVA with Bonferroni's multiple-comparison post test.

  • ↵**p < 0.01;

  • ↵***p < 0.001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Hypothalamus ventromedial nucleus Neuropeptide Y sensitive neurons rheobase (pA) 35.1 ± 2.3 (147) 35.1 (pA) Data Table
Other Hypothalamus ventromedial nucleus Neuropeptide Y sensitive neurons resting membrane potential (mV) -68.9 ± 0.6 (147) -68.9 (mV) Data Table
Other Hypothalamus ventromedial nucleus Neuropeptide Y sensitive neurons input resistance (MΩ) 388.3 ± 13.0 (147) 388.3 (MΩ) Data Table