Probabilities of finding striatal cell types when targeting interneurons in acute brain slices
The Lhx6-EGFP line enables highly efficient targeting of striatal interneurons. All fluorescent neurons targeted in Lhx6-EGFP
mice were GABAergic interneurons. In contrast, targeting nonfluorescent neurons in D1-D2-XFP mice yielded GABAergic interneurons
75% of the time. Note that <10% of nonfluorescent neurons in D1-D2-XFP mice were MSNs, suggesting highly efficient labeling
of D1- and D2-MSNs by D1-Tmt and D2-GFP fluorescence, respectively. The last column shows the low success rate for targeting
GABAergic interneurons using traditional methods in wild-type mice.