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Article: Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal.

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Wu X; Shi M; Wei C; Yang M; Liu Y; Liu Z; Zhang X; Ren W
J. Neurosci. Res., 2012


Table I. Effects of 10 Days of Withdrawal After Repeated Morphine Exposure on Membrane Properties of MSNs*
TreatmentSalineMorphineMorphine + LY379268
  • *

    Values represent the mean ± SEM for the number of neurons indicated. One-way ANOVA, AP H-W of treatment, F2,38 = 7.769, P = 0.002; LSD post hoc test.

No. of neurons16149
Passive membrane properties
 RMP (mV)−81.99 ± 0.33−82.15 ± 0.51−79.46 ± 1.02
 Rin (MΩ)183.31 ± 12.32201.55 ± 11.12161.99 ± 12.24
Active membrane properties
 AP amplitude (mV)66.68 ± 2.9571.68 ± 1.5272.38 ± 1.70
 AP H-W (msec)1.77 ± 0.061.56 ± 0.031.86 ± 0.07
 AHP amplitude (mV)8.70 ± 0.919.36 ± 0.729.62 ± 0.49

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron input resistance (MΩ) 183.31 ± 12.32 (16) 183.31 (MΩ) Data Table
Nucleus accumbens medium spiny neuron spike amplitude (mV) 66.68 ± 2.95 (16) 66.68 (mV) Data Table
Nucleus accumbens medium spiny neuron spike half-width (msec) 1.77 ± 0.06 (16) 1.77 (ms) Data Table
Nucleus accumbens medium spiny neuron AHP amplitude (mV) 8.7 ± 0.91 (16) 8.7 (mV) Data Table
Nucleus accumbens medium spiny neuron resting membrane potential (mV) -81.99 ± 0.33 (16) -81.99 (mV) Data Table