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Article: mGluR1 agonists elicit a Ca 2+ signal and membrane hyperpolarization mediated by apamin-sensitive potassium channels in immature rat purkinje neurons.

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Netzeband JG; Gruol DL
J. Neurosci. Res., 2008


Table I. Summary of Effects of DHPG on Intracellular Calcium and Membrane Potential
 Immature (6–8 DlV) (n = 34)Intermediate (10–15 DlV) (n = 21)Mature (18–26 DlV) (n = 10)

  • All values are the means ± SEMs. Means for resting calcium, DHPG-evoked calcium signal, and resting membrane potential are from all cells studied and represent measurements from the somatic region. For the DHPG-evoked membrane response, only those cells exhibiting a particular component of the response were used to obtain the mean. The number of responders is indicated in parentheses.

  • ☆

    Significant difference from the immature neurons (6–8 DIV) at P < 0.05;

  • †

    significant difference from the intermediate neurons at P < 0.05 (by ANOVA and post hoc analysis using the Fisher protected least significant difference test); n.d., not detected.

Resting calcium (nM)64 ± 458 ± 766 ± 8
DHPG-evoked calcium signal   
 Peak amplitude (nM)95 ± 762 ± 6☆54 ± 7☆
 Area (nM × sec)821 ± 80437 ± 76☆961 ± 181†
 Time-to-peak (sec)2.9 ± 0.13.0 ± 0.26.7 ± 0.9☆†
Resting membrane potential (mV)−51 ± 1−50 ± 1−55 ± 1☆†
DHPG-evoked membrane response   
 Initial hyperpolarization(n = 34 of 34)(n = 19 of 21)(n = 0 of 10)
  Peak amplitude (mV)−19.5 ± 1.0−6.9 ± 1.3☆n.d.
  Time-to-peak (sec)1.4 ± 0.11.1 ± 0.1☆n.d.
  Total duration (sec)5.1 ± 0.51.6 ± 0.2☆n.d.
 Depolarization(n =17 of 34)(n = 15 of 21)(n = 6 of 10)
  Peak amplitude (mV)3.0 ± 0.43.3 ± 0.67.4 ± 1.4☆†
  Time-to-peak (sec)11.7 ± 1.06.1 ± 0.5☆7.8 ± 3.5
  Total duration (sec)15.9 ± 1.217.6 ± 2.324.6 ± 2.5†
 Late hyperpolarization(n = 2 of 34)(n = 10 of 21)(n = 5 of 10)
  Peak amplitude (mV)−2.0 ± 0.4−1.8 ± 0.3−2.5 ± 0.5

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum Purkinje cell Purkinje neurons AHP amplitude (nM) 95.0 ± 7.0 -- Data Table
Cerebellum Purkinje cell AHP amplitude (nM) 62.0 ± 6.0 -- Data Table
Cerebellum Purkinje cell AHP amplitude (nM) 54.0 ± 7.0 -- Data Table
Cerebellum Purkinje cell Purkinje neurons cell surface area 821.0 ± 80.0 -- Data Table
Cerebellum Purkinje cell cell surface area 437.0 ± 76.0 -- Data Table
Cerebellum Purkinje cell cell surface area 961.0 ± 181.0 -- Data Table
Cerebellum Purkinje cell Purkinje neurons resting membrane potential (mV) -51.0 ± 1.0 -- Data Table
Cerebellum Purkinje cell resting membrane potential (mV) -50.0 ± 1.0 -- Data Table
Cerebellum Purkinje cell resting membrane potential (mV) -55.0 ± 1.0 -- Data Table
Cerebellum Purkinje cell Purkinje neurons AHP amplitude (mV) -19.5 ± 1.0 -- Data Table
Cerebellum Purkinje cell AHP amplitude (mV) -6.9 ± 1.3 -- Data Table
Cerebellum Purkinje cell Purkinje neurons AHP amplitude (mV) 3.0 ± 0.4 -- Data Table
Cerebellum Purkinje cell AHP amplitude (mV) 3.3 ± 0.6 -- Data Table
Cerebellum Purkinje cell AHP amplitude (mV) 7.4 ± 1.4 -- Data Table
Cerebellum Purkinje cell Purkinje neurons AHP amplitude (mV) -2.0 ± 0.4 -- Data Table
Cerebellum Purkinje cell AHP amplitude (mV) -1.8 ± 0.3 -- Data Table
Cerebellum Purkinje cell AHP amplitude (mV) -2.5 ± 0.5 -- Data Table