AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL
J. Neurosci., 2009


Table 2.

Biophysical parameters of sodium current in SNaIIa cells compared with SNaIIa cells coexpressing β1WT or p.R125C

SNaIIa SNaIIa + β1WT SNaIIa + p.R125C
Voltage dependence of activation
    V1/2 (mV) −16.04 ± 1.02 −20.63 ± 1.22 −17.50 ± 1.50
    k −7.92 ± 0.46 −7.15 ± 0.22 −7.79 ± 0.38
    n 17 15 18
Voltage dependence of inactivation
    V1/2 (mV) −58.26 ± 1.49 −66.72 ± 1.47* −59.66 ± 1.05†
    k 4.76 ± 0.12 5.11 ± 0.08 5.59 ± 0.17
    C 0.02 ± 0.01 0.02 ± 0.01 0.05 ± 0.00
    n 13 14 16
Kinetics of inactivation
    τslow (ms) 4.82 ± 0.75 6.26 ± 1.20 4.71 ± 1.60
    Amplitudeslow (%) 6.41 ± 0.99 0.04 ± 0.00‡ 10.62 ± 1.60§
    τfast (ms) 0.57 ± 0.02 0.49 ± 0.04 0.56 ± 0.33
    Amplitudefast (%) 93.58 ± 0.99 97.15 ± 0.01‡ 89.37 ± 1.60§
    n 12 14 10
Persistent current
    % of peak current 2.70 ± 0.70 0.00 ± 0.00* 1.88 ± 0.41†
    n 12 13 14

  • Data are mean ± SEM.

  • ↵*p < 0.005 compared with Nav1.2.

  • ↵†p < 0.005 compared with β1WT.

  • ↵‡p < 0.001 compared with Nav1.2.

  • ↵§p < 0.001 compared with β1WT.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source