Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL J. Neurosci., 2009
Table 2.
Biophysical parameters of sodium current in SNaIIa cells compared with SNaIIa cells coexpressing β1WT or p.R125C
SNaIIa | SNaIIa + β1WT | SNaIIa + p.R125C | |
---|---|---|---|
Voltage dependence of activation | |||
V1/2 (mV) | −16.04 ± 1.02 | −20.63 ± 1.22 | −17.50 ± 1.50 |
k | −7.92 ± 0.46 | −7.15 ± 0.22 | −7.79 ± 0.38 |
n | 17 | 15 | 18 |
Voltage dependence of inactivation | |||
V1/2 (mV) | −58.26 ± 1.49 | −66.72 ± 1.47* | −59.66 ± 1.05† |
k | 4.76 ± 0.12 | 5.11 ± 0.08 | 5.59 ± 0.17 |
C | 0.02 ± 0.01 | 0.02 ± 0.01 | 0.05 ± 0.00 |
n | 13 | 14 | 16 |
Kinetics of inactivation | |||
τslow (ms) | 4.82 ± 0.75 | 6.26 ± 1.20 | 4.71 ± 1.60 |
Amplitudeslow (%) | 6.41 ± 0.99 | 0.04 ± 0.00‡ | 10.62 ± 1.60§ |
τfast (ms) | 0.57 ± 0.02 | 0.49 ± 0.04 | 0.56 ± 0.33 |
Amplitudefast (%) | 93.58 ± 0.99 | 97.15 ± 0.01‡ | 89.37 ± 1.60§ |
n | 12 | 14 | 10 |
Persistent current | |||
% of peak current | 2.70 ± 0.70 | 0.00 ± 0.00* | 1.88 ± 0.41† |
n | 12 | 13 | 14 |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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