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Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.

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Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL
J. Neurosci., 2009


Table 3.

Biophysical parameters of sodium currents expressed by Nav1.2 alone or Nav1.2 coexpressed with β1WT or R125C in Xenopus oocytes

Nav1.2 Nav1.2 + β1WT Nav1.2 + p.R125C
Voltage dependence of activation
    V1/2 (mV) −18.81 ± 1.38 −20.06 ± 3.08 −16.81 ± 1.29
    k −6.88 ± 0.31 −7.8 ± 0.18 −8.59 ± 0.51
    n 10 7 13
Voltage dependence of inactivation
    V1/2 (mV) −51.69 ± 2.60 −58.11 ± 1.33 −58.17 ± 1.41
    k 10.12 ± 0.31 7.18 ± 0.49* 6.61 ± 0.28*
    C −0.01 ± 0.00 −0.02 ± 0.00 0.01 ± 0.01
    n 10 9 14
Kinetics of inactivation
    τslow (ms) 7.41 ± 0.68 5.10 ± 0.50 6.05 ± 0.72
    Amplitudeslow (%) 46.42 ± 3.09 10.10 ± 1.29* 20.71 ± 1.44*
    τfast (ms) 1.43 ± 0.31 0.49 ± 0.04* 0.68 ± 0.05*
    Amplitudefast (%) 53.57 ± 3.1 89.89 ± 2* 79.28 ± 2.11*
    n 10 6 9

  • Data are mean ± SEM.

  • ↵*p ≤ 0.001 compared with Nav1.2.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source