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Article: M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Gulledge AT; Bucci DJ; Zhang SS; Matsui M; Yeh HH J. Neurosci., 2009
Comparison of tonic cholinergic responses in pyramidal neurons expressing different mAChR subunits
| Genotype | Layer | n | Δ RMP (mV) | Δ AHP amplitude (mV) | Δ ADP amplitude (mV) |
|---|---|---|---|---|---|
| Wild type | 2/3 | 11 | +1.4 ± 3.3 | −1.2 ± 1.1 | +0.7 ± 0.7 |
| M1 KO | 2/3 | 9 | −1.0 ± 1.6* | −0.7 ± 0.7 | +0.2 ± 0.4 |
| Wild type | 5 | 10 | +3.9 ± 2.1 | −1.9 ± 1.1 | +2.6 ± 1.2 |
| M1 KO | 5 | 10 | +0.9 ± 1.7* | +0.3 ± 0.8* | −0.0 ± 0.6* |
| M3 KO | 5 | 9 | +3.3 ± 2.9 | +0.4 ± 0.9* | +1.8 ± 1.2 |
| M5 KO | 5 | 7 | +5.0 ± 2.7 | −2.2 ± 1.8 | +2.9 ± 2.0 |
| M3/M5 KO | 5 | 11 | +5.3 ± 2.8 | −0.1 ± 1.4* | +1.8 ± 0.6 |
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Cholinergic responses evoked by bath-applied carbachol (10 μm for 10 min). Changes in RMP, AHP, and ADP amplitudes were measured at the end of carbachol treatment and relative to values measured in baseline conditions. Bold numbers indicate p < 0.05 for carbachol effects on RMP and/or AHP and ADP amplitudes. Asterisks indicate p < 0.01 when compared to wild-type neurons in the same layer. KO, genetic knock-out for indicated mAChR subtype.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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