Article: Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ahlenius H; Visan V; Kokaia M; Lindvall O; Kokaia Z J. Neurosci., 2009
Embryonic | Adult | Aged | ||||
---|---|---|---|---|---|---|
Proliferation | Differentiation | Proliferation | Differentiation | Proliferation | Differentiation | |
Capacitance (pF) | 11.9 ± 0.7 (n = 30) | 23.3 ± 2.3 (n = 27) | 15.1 ± 0.8 (n = 27) | 19.1 ± 2.1 (n = 17) | 13 ± 0.1 (n = 24) | 23.2 ± 1.8 (n = 15) |
Input resistance (GΩ) | 1.7 ± 0.3 (n = 16) | 1.8 ± 0.3 (n = 19) | 1.2 ± 0.4 (n = 13) | 2 ± 0.3 (n = 13) | 2.9 ± 0.8 (n = 8) | 2 ± 0.4 (n = 12) |
Resting membrane potential (mV) | −59.7 ± 2.8 (n = 20) | −62.5 ± 1.0 (n = 25) | −65.1 ± 4.5 (n = 15) | −65.6 ± 2.8 (n = 16) | −56.8 ± 5.4 (n = 14) | −66.7 ± 2.3 (n = 12) |
Action potential threshold (mV) | −31.3 ± 1.2 (n = 23) | −29.3 ± 1.5 (n = 16) | −29.4 ± 1 (n = 11) | |||
Action potential amplitude (mV) | 49.9 ± 2.2 (n = 23) | 45.2 ± 3.9 (n = 16) | 39.8 ± 2.3 (n = 11) | |||
Action potential duration (ms) | 4.5 ± 0.3 (n = 23) | 5.0 ± 0.5 (n = 16) | 3.9 ± 0.4 (n = 11) | |||
Action potential after-hyperpolarization (mV) | 14.6 ± 1.2 (n = 23) | 13.2 ± 1.8 (n = 16) | 14.3 ± 2.1 (n = 11) |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Other | subventricular zone proliferating progenitor cells | input resistance (GΩ) | 1.2 ± 0.4 | 1200.0 (MΩ) | Data Table |
Other | subventricular zone differentiating progenitor cells | input resistance (GΩ) | 2.0 ± 0.3 | 2000.0 (MΩ) | Data Table |
Other | subventricular zone proliferating progenitor cells | input resistance (GΩ) | 2.9 ± 0.8 | 2900.0 (MΩ) | Data Table |
Other | subventricular zone differentiating progenitor cells | input resistance (GΩ) | 2.0 ± 0.4 | 2000.0 (MΩ) | Data Table |
Other | subventricular zone proliferating progenitor cells | resting membrane potential (mV) | -65.1 ± 4.5 | -65.1 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | resting membrane potential (mV) | -65.6 ± 2.8 | -65.6 (mV) | Data Table |
Other | subventricular zone proliferating progenitor cells | resting membrane potential (mV) | -56.8 ± 5.4 | -56.8 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | resting membrane potential (mV) | -66.7 ± 2.3 | -66.7 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | spike threshold (mV) | -29.3 ± 1.5 | -29.3 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | spike threshold (mV) | -29.4 ± 1.0 | -29.4 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | spike amplitude (mV) | 45.2 ± 3.9 | 45.2 (mV) | Data Table |
Other | subventricular zone differentiating progenitor cells | spike amplitude (mV) | 39.8 ± 2.3 | 39.8 (mV) | Data Table |
Other | subventricular zone proliferating progenitor cells | cell capacitance (pF) | 15.1 ± 0.8 | 15.1 (pF) | Data Table |
Other | subventricular zone differentiating progenitor cells | AHP duration (ms) | 5.0 ± 0.5 | 5.0 (ms) | Data Table |
Other | subventricular zone differentiating progenitor cells | AHP duration (ms) | 3.9 ± 0.4 | 3.9 (ms) | Data Table |
Other | subventricular zone differentiating progenitor cells | AHP duration (mV) | 13.2 ± 1.8 | -- | Data Table |
Other | subventricular zone differentiating progenitor cells | AHP duration (mV) | 14.3 ± 2.1 | -- | Data Table |
Other | subventricular zone differentiating progenitor cells | cell capacitance (pF) | 19.1 ± 2.1 | 19.1 (pF) | Data Table |
Other | subventricular zone proliferating progenitor cells | cell capacitance (pF) | 13.0 ± 0.1 | 13.0 (pF) | Data Table |
Other | subventricular zone differentiating progenitor cells | cell capacitance (pF) | 23.2 ± 1.8 | 23.2 (pF) | Data Table |