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Article: Local circuitry involving parvalbumin-positive basket cells in the CA2 region of the hippocampus.

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Mercer A; Eastlake K; Trigg HL; Thomson AM
Hippocampus, 2012


Table 4. Effect of the IhBlocker ZD 7288 on Synaptic Properties and Spontaneous Synaptic Activity in Wide Dendritic arbor CA2 Basket Cells
 Control+ZD 7288

  1. The addition of ZD 7288 did not result in significant changes in the time course or amplitude of EPSPs elicited by identified CA2 pyramidal cells, or of spontaneous EPSPs. There was, however, a significant increase in the frequency of spontaneous EPSPs recorded in CA2 interneurons (Student's unpaired test, P< 0.05).

EPSP amplitude (mV)1.7 ± 0.81.6 ± 0.7
EPSP half width (ms)8.5 ± 210.5 ± 1.4
EPSP 10–90% rise time (ms)1.3 ± 0.61.2 ± 0.5
PPR 10–20 ms1.15 ± 0.21.09 ± 0.2
Spontaneous EPSP frequency (Hz)12 ± 2.622.2 ± 6.7*
Spontaneous EPSP amplitude (mV)2.7 ± 0.32.5 ± 0.6
Spontaneous EPSP half width (ms)9.1 ± 19.2 ± 2.1

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