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Article: Failure to mount adaptive responses to stress results in dysregulation and cell death in the midbrain raphe.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McEuen JG; Beck SG; Bale TL J. Neurosci., 2008
Table 1.
Serum corticosterone measurements in WT and stress-sensitive (KO) mice showing continued stress response throughout the chronic stress paradigm (n = 6–7)
| Corticosterone (ng/ml) | ||||
|---|---|---|---|---|
| Week 1 | Week 2 | Week 3 | Week 4 | |
| Basal (0 min) | ||||
| WT CTRL | 26.8 ± 3.5 | 16.0 ± 2.0 | 22.1 ± 8.5 | 28.1 ± 4.2 |
| KO CTRL | 28.4 ± 6.3 | 32.7 ± 7.5 | 44.1 ± 25.3 | 22.7 ± 3.9 |
| WT STRESS | 42.7 ± 13.5 | 25.4 ± 2.9 | 36.7 ± 12.5 | 37.1 ± 14.3 |
| KO STRESS | 26.2 ± 7.2 | 39.6 ± 15.9 | 24.6 ± 1.8 | 28.2 ± 10.0 |
| Stressed (15 min) | ||||
| WT CTRL | 128.9 ± 18.6 | 118.7 ± 10.7 | 155.4 ± 8.5 | 155.7 ± 16.4 |
| KO CTRL | 198.8 ± 26.0 | 225 ± 52.2 | 205.8 ± 25.3 | 156.5 ±17.2 |
| WT CVS | 172.5 ± 24.1 | 173.6 ± 29.4 | 176.6 ± 12.1 | 177.7 ± 13.0 |
| KO CVS | 163.2 ± 43.3 | 161.1 ± 22.2 | 156.3 ± 16.5 | 151 ± 12.3 |
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Stressed mice (chronic variable stress) of each genotype were compared with unstressed littermates (CTRL). Samples were taken before onset (Basal) and at completion (Stressed) of a 15 min restraint stress. Values are expressed as mean ± SEM.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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