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Article: Altered neuron excitability and synaptic plasticity in the cerebellar granular layer of juvenile prion protein knock-out mice with impaired motor control.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Prestori F; Rossi P; Bearzatto B; Lainé J; Necchi D; Diwakar S; Schiffmann SN; Axelrad H; D'Angelo E J. Neurosci., 2008
Properties of whole-cell recordings in mice granule cells
| C57BL/6J (n = 22) | C57 × Sv129 (n = 23) | PrP0/0 fast (n = 12) | PrP0/0 slow (n = 8) | |
|---|---|---|---|---|
| Rm (GΩ) | 1.9 ± 0.2* | 1.6 ± 0.2* | 1.9 ± 0.2* | 3.0 ± 0.5 |
| Cm (pF) | 3.8 ± 0.2 | 3.9 ± 0.2 | 4.0 ± 0.4 | 4.6 ± 0.4 |
| Rs (MΩ) | 21.2 ± 1.6 | 20.5 ± 1.7 | 19.8 ± 3.3 | 17.7 ± 2.2 |
| fVC (kHz) | 2.3 ± 0.2 | 2.2 ± 0.1 | 2.3 ± 0.2 | 2.2 ± 0.2 |
| τVC (μs) | 81.6 ± 8.1 | 76.0 ± 5.0 | 75.1 ± 8.9 | 77.2 ± 7.3 |
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The data were obtained using K-gluconate intracellular solution and analyzing current transients elicited by −10 mV voltage-clamp steps delivered from the holding potential of −70 mV. The number of observations is indicated, and statistical significance is reported in comparisons with slow-spiking PrP0/0 granule cells.
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↵*p < 0.05, unpaired t test.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Cerebellum granule cell | access resistance (MΩ) | 21.2 ± 1.6 (22) | 21.2 (MΩ) | Data Table | |
| Cerebellum granule cell | input resistance (GΩ) | 1.9 ± 0.2 (22) | 1900.0 (MΩ) | Data Table | |
| Cerebellum granule cell | cell capacitance (pF) | 3.8 ± 0.2 (22) | 3.8 (pF) | Data Table |