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Article: cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons.

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Lopez de Armentia M; Jancic D; Olivares R; Alarcon JM; Kandel ER; Barco A
J. Neurosci., 2007


Table 1.

Electrophysiological properties of CA1 pyramidal neurons in VP16–CREBhigh mice

Group of mice (n = neurons, mice) Em (mV) Rin (MΩ) τ (ms) AP amplitude (mV) AP50 (ms) dV/dtmax (V/s) Threshold (mV) Medium IAHP (pA) Slow IAHP (pA)
VP16–CREBhigh On (n = 22, 7) −56 ± 1.1 210 ± 20.7 21 ± 1.6 112 ± 1.6 0.99 ± 0.05 251 ± 10.4 −33 ± 1.2 120 ± 13.1 15 ± 2.5
Wild-type On (n = 16, 5) −58 ± 2.1 181 ± 17.3 25 ± 2.7 119 ± 1.3 1.01 ± 0.03 309 ± 9.8 −39 ± 0.7 251 ± 19.8 41 ± 6.7
p 0.40 0.29 0.13 0.004 0.71 <0.001 <0.001 <0.001 <0.001
VP16–CREBhigh On/Off (n = 22, 5) −60 ± 1.6 168 ± 12.5 23 ± 1.9 120 ± 1.3 0.99 ± 0.04 316 ± 9.9 −39 ± 0.5 224 ± 15.9 36 ± 3.3
Wild-type On/Off (n = 19, 4) −61 ± 1.7 157 ± 10.4 23 ± 1.0 120 ± 1.2 1.01 ± 0.03 306 ± 6.0 −39 ± 0.8 231 ± 15.6 44 ± 3.5
p 0.77 0.51 0.91 0.93 0.74 0.40 0.84 0.27 0.11
VP16–CREBhigh Off (n = 13, 2) −61 ± 2.1 137 ± 10.0 18 ± 1.5 116 ± 2.2 0.89 ± 0.04 310 ± 14.7 −40 ± 1.1 211 ± 16.6 45 ± 8.6
Wild-type Off (n = 19, 3) −57 ± 1.4 134 ± 10.3 19 ± 1.2 119 ± 1.2 0.86 ± 0.03 321 ± 8.4 −39 ± 1.0 243 ± 13.2 47 ± 7.6
p 0.13 0.95 0.61 0.14 0.43 0.40 0.45 0.12 0.88
  • τ, Membrane time constant; AP50, AP duration at 50% amplitude; dV/dtmax, maximum rate of depolarization. In VP16–CREBhigh On mice, the recordings were performed 10 d after transgene expression. In VP16–CREBhigh On/Off mice, the transgene was expressed for 10 d and then silenced for 10 additional days. In both cases, transgene expression was turned on when the mice were 4 weeks old. VP16–CREBhigh Off mice were 10 weeks old when the experiments were performed. In all these experiments, wild-type mice were housed and maintained in the same conditions than their mutant littermates.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -57.0 ± 1.4 (19) -57.0 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 134.0 ± 10.3 (19) 134.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 19.0 ± 1.2 (19) 19.0 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 119.0 ± 1.2 (19) 119.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 0.86 ± 0.03 (19) 0.86 (ms) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope (V/s) 321.0 ± 8.4 (19) 321.0 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -39.0 ± 1.0 (19) -39.0 (mV) Data Table