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Article: HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex.

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Nolan MF; Dudman JT; Dodson PD; Santoro B
J. Neurosci., 2007


Table 1.

Membrane properties of MEC stellate cells from HCN1+/+ and HCN1−/− mice

HCN1+/+ HCN1−/− p
Resting membrane potential (mV) −68.5 ± 0.6 −75.0 ± 0.5 5.2e-13
Input resistance (−ve) (MΩ) 43.9 ± 3.2 73.2 ± 4.7 2.8e-6
Input resistance (+ve) (MΩ) 55.2 ± 3.9 87.3 ± 7.1 1.8e-4
Time constant (−ve) (ms) 9.3 ± 0.9 20.4 ± 1.3 6.1e-10
Time constant (+ve) (ms) 10.3 ± 0.8 19.8 ± 1.6 1.1e-6
Sag 0.62 ± 0.01 0.80 ± 0.01 1.2e-17

  • Input resistance and membrane time constant were calculated from membrane potential responses to negative current steps (−ve) and positive current steps (+ve). The membrane potential sag ratio (Sag) was calculated from responses to negative current steps. For HCN1+/+ mice, n = 45 for resting potential and input resistance and n = 41 otherwise. For HCN1−/− mice, n = 53 for resting potential and input resistance and n = 43 for other properties.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial entorhinal cortex layer II stellate cell input resistance 55.2 ± 3.9 (45) 55.2 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell membrane time constant 9.3 ± 0.9 (45) 9.3 (ms) Data Table
Medial entorhinal cortex layer II stellate cell resting membrane potential (mV) -68.5 ± 0.6 (45) -68.5 (mV) Data Table
Medial entorhinal cortex layer II stellate cell sag ratio 0.62 ± 0.01 (45) 0.62 (ratio) Data Table
Medial entorhinal cortex layer II stellate cell input resistance 43.9 ± 3.2 (45) 43.9 (MΩ) Data Table