Article: HCN1 channels control resting and active integrative properties of stellate cells from layer II of the entorhinal cortex.
|Resting membrane potential (mV)||−68.5 ± 0.6||−75.0 ± 0.5||5.2e-13|
|Input resistance (−ve) (MΩ)||43.9 ± 3.2||73.2 ± 4.7||2.8e-6|
|Input resistance (+ve) (MΩ)||55.2 ± 3.9||87.3 ± 7.1||1.8e-4|
|Time constant (−ve) (ms)||9.3 ± 0.9||20.4 ± 1.3||6.1e-10|
|Time constant (+ve) (ms)||10.3 ± 0.8||19.8 ± 1.6||1.1e-6|
|Sag||0.62 ± 0.01||0.80 ± 0.01||1.2e-17|
Input resistance and membrane time constant were calculated from membrane potential responses to negative current steps (−ve) and positive current steps (+ve). The membrane potential sag ratio (Sag) was calculated from responses to negative current steps. For HCN1+/+ mice, n = 45 for resting potential and input resistance and n = 41 otherwise. For HCN1−/− mice, n = 53 for resting potential and input resistance and n = 43 for other properties.