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Article: Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.

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Goldfarb M; Schoorlemmer J; Williams A; Diwakar S; Wang Q; Huang X; Giza J; Tchetchik D; Kelley K; Vega A; Matthews G; Rossi P; Ornitz DM; D'Angelo E
Neuron, 2007


Table 1Summary of Electrophysiological Data
A. Cerebellar Slice Recordings—Physiological Solutions
Wild-TypeFhf1−/−Fhf4−/−Fhf1−/−Fhf4−/−
# Cells recorded7447
Rin (GΩ)1.53 ± 0.701.40 ± 0.420.47 ± 0.200.95 ± 0.51
Cm (pF)4.62 ± 0.964.24 ± 1.404.47 ± 1.354.35 ± 1.16
Rs (MΩ)26.6 ± 14.025.2 ± 7.219.1 ± 6.322.3 ± 8.9
Iin-peak at −10 mV (pA)−1012 ± 287−933 ± 360−1860 ± 707−1033 ± 359
Iout-peak at +20 mV (pA)999 ± 421844 ± 446956 ± 440974 ± 950
Vrest (mV)−69.4 ± 8.4−72.3 ± 4.9−55.3 ± 10.7−59.9 ± 6.3
Vthreshold (mV)−49.6 ± 4.9−50.9 ± 9.8−43.4 ± 4.4−40.2 ± 8.7∗
Ithreshold x Rin (mV)29.6 ± 6.527.4 ± 7.230.4 ± 4.639.4 ± 11.4
Vahp (mV)−59.8 ± 7.3−61.9 ± 4.5−50.4 ± 3.9−46.8 ± 2.5∗
Maximum # spikes in 800 ms47.0 ± 20.948.0 ± 20.68.5 ± 4.7∗∗2.3 ± 2.2∗∗#
B. Cultured Granule Cell Recordings—Sodium Currents Only
Wild-Type (# Cells)Fhf1−/−Fhf4−/− (# Cells)t Test
Cm (pF)4.74 ± 0.95 (9)3.86 ± 0.83 (11)
Rs (MΩ)12.1 ± 3.5 (9)13.5 ± 7.5 (11)
Frequency voltage clamp (kHz)2.99 ± 0.58 (9)3.58 ± 0.95 (11)
Transient INa-Peak at −15 mV (pA)−431 ± 166 (9)−536 ± 326 (11)
Resurgent INa 5 mV to −85 mV (pA)−117 ± 78 (9)−134 ± 76 (9)
Persistent INa at −35 mV (pA)−26 ± 7 (9)−12 ± 6 (9)p < 0.0003
V1/2 Activation (mV)−33.3 ± 4.2 (9)−36.5 ± 7.5 (11)
k Activation (mV)5.2 ± 0.7 (9)4.6 ± 1.2 (11)
V1/2 Inactivation (mV)−59.1 ± 4.9 (8)−72.8 ± 4.3 (9)p < 0.00003
k Inactivation (mV)−5.8 ± 0.6 (8)−5.3 ± 0.6 (9)
τFast Inactivation at −15 mV (msec)1.10 ± 0.24 (6)0.49 ± 0.08 (10)p < 0.001
τFast Inactivation at −5 mV (msec)0.64 ± 0.12 (6)0.33 ± 0.05 (10)p < 0.0003
τRecovery at −85 mV (ms)3.80 ± 0.80 (7)5.88 ± 0.88 (7)p < 0.001
C. Cerebellar Slice Recordings—Sodium Currents Only
Wild-Type (# Cells)Fhf1−/−Fhf4−/− (# Cells)t Test
Cm (pF)4.58 ± 0.99 (14)3.89 ± 0.67 (15)
Rs (MΩ)16.0 ± 6.7 (14)17.9 ± 10.4 (15)
Frequency voltage clamp (kHz)2.61 ± 1.24 (14)2.88 ± 1.03 (15)
Transient INa-Peak at −15 mV (pA)−907 ± 367 (11)−551 ± 201 (10)p < 0.02
Resurgent INa 5 mV to −85 mV (pA)−65 ± 46 (9)−28 ± 26 (10)
V1/2 Inactivation (mV)−55.6 ± 2.0 (6)−69.9 ± 5.3 (8)p < 0.00005
k Inactivation (mV)−4.8 ± 0.9 (6)−5.2 ± 0.9 (8)
τ Recovery at −85 mV (ms)3.04 ± 0.20 (4)7.22 ± 3.31 (6)p < 0.025
∗Significant deficit (p < 0.05) by ANOVA. ∗∗Significant deficit (p < 0.01) by ANOVA. #Significant versus Fhf4−/− (p < 0.05) by t test.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum granule cell input resistance (GΩ) 1.53 ± 0.7 (7) 1530.0 (MΩ) Data Table
Cerebellum granule cell cell capacitance (pF) 4.62 ± 0.96 (7) 4.62 (pF) Data Table
Cerebellum granule cell access resistance (MΩ) 26.6 ± 14.0 (7) 26.6 (MΩ) Data Table
Cerebellum granule cell resting membrane potential (mV) -69.4 ± 8.4 (7) -69.4 (mV) Data Table
Cerebellum granule cell spike threshold (mV) -49.6 ± 4.9 (7) -49.6 (mV) Data Table
Cerebellum granule cell AHP voltage (mV) -59.8 ± 7.3 (7) -59.8 (mV) Data Table