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Article: The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM J. Neurosci., 2007
Table 1.
Voltage-gated Na+ currents in rat hippocampal neurons
| Cells | Peak density (pA/pF) | V1/2 (act) (mV) | kact (mV) | V1/2 (inact) (mV) | kinact (mV) |
|---|---|---|---|---|---|
| GFP | −150 ± 15 (38) | −27 ± 1 (22) | 6.0 ± 0.3 (22) | −60 ± 1 (27) | 6.1 ± 0.2 (27) |
| FGF14 | −242 ± 24 (17)* | −33 ± 1 (13)** | 3.6 ± 0.3 (13)*** | −56 ± 1 (10)** | 5.4 ± 0.2 (10) |
| FGF14F145S | −61 ± 13 (29)*** | −22 ± 2 (9)** | 6.4 ± 0.3 (9) | −66 ± 1 (9)** | 8.0 ± 0.5 (9)*** |
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All values are means ± SEM; numbers in parentheses are the numbers of cells analyzed. Values are significantly different from those determined in cells expressing GFP alone at the *p < 0.01, **p < 0.005, and ***p < 0.001 levels.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
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