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Article: Altered intrinsic properties of neuronal subtypes in malformed epileptogenic cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
George AL; Jacobs KM
Brain Res., 2011


Table 1Intrinsic properties of layer V interneurons and pyramidal cells.
Electrophysiological parameterFSLTSPyr
Control (n=34)Control (n=33)Control (n=29)
PMG (n=30)PMG (n=23)PMG (n=22)
1st spike duration, ms0.77±0.04§1.08±0.051.86±0.08
0.81±0.06§1.03±0.052.03±0.12
2nd spike duration, ms0.79±0.04§1.23±0.062.35±0.13
0.84±0.07§1.17±0.062.84±0.22**
Duration increase, %2.8±0.6§13.4±1.425.8±4.4
2.7±1.0§12.6±1.739.6±6.9
1st spike AHP, mV−11.8±0.6§−8.6±0.6−3.9±0.7
−11.5±0.6§−7.2±0.9−3.3±0.6
2nd spike AHP, mV−14.9±0.6§−11.2±0.6−14.0±0.8
−14.6±0.6§−10.0±0.9−14.8±0.8
Early adaptation ratio0.08±0.020.11±0.020.22±0.02
0.09±0.020.07±0.010.16±0.03
Late adaptation ratio0.86±0.02§0.55±0.030.77±0.02
0.83±0.01§0.55±0.040.76±0.01
Accommodative hump, mV4.8±0.6§1.5±0.23.4±1.1
4.3±0.6§2.2±0.63.1±1.3
Minimal frequency, Hz32.4±3.6§9.2±0.66.3±0.3
25.5±3.3§11.6±2.36.7±0.5
Time for min freq., ms188±21201±14175±9
171±17170±16176±12
Values are means±SEM. n, number of cells; FS, fast-spiking cells; LTS, low-threshold spiking cells; Pyr, pyramidal cells; ** indicates significant difference between control and PMG for an indivdual neuronal subtype, Student's t-test, p<0.05; § indicates significant difference between FS and LTS within a particular subject group, Student's t-test, p<0.05.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron spike half-width (ms) 0.77 ± 0.04 (34) 0.77 (ms) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron spike half-width (ms) 1.08 ± 0.05 (33) 1.08 (ms) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell spike half-width (ms) 1.86 ± 0.08 (29) 1.86 (ms) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron AHP amplitude (mV) -11.8 ± 0.6 (34) 11.8 (mV) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron AHP amplitude (mV) -8.6 ± 0.6 (33) 8.6 (mV) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell AHP amplitude (mV) -3.9 ± 0.7 (29) 3.9 (mV) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron adaptation ratio 0.08 ± 0.02 (34) 0.08 (ratio) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron adaptation ratio 0.11 ± 0.02 (33) 0.11 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell adaptation ratio 0.22 ± 0.02 (29) 0.22 (ratio) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron adaptation ratio 0.86 ± 0.02 (34) 0.86 (ratio) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron adaptation ratio 0.55 ± 0.03 (33) 0.55 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell adaptation ratio 0.77 ± 0.02 (29) 0.77 (ratio) Data Table
Neocortex basket cell Somatosensory cortex layer 5 multipolar fast-spiking parvalbumin positive interneuron firing frequency (Hz) 32.4 ± 3.6 (34) 32.4 (Hz) Data Table
Neocortex Martinotti cell Somatosensory cortex layer 5 low threshold-spiking interneuron firing frequency (Hz) 9.2 ± 0.6 (33) 9.2 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 Somatosensory cortex layer 5 apical pyramidal cell firing frequency (Hz) 6.3 ± 0.3 (29) 6.3 (Hz) Data Table