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Article: Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons.

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Wang D; Schreurs BG
Neurosci. Lett., 2010


Table 1Summary of membrane properties of rabbit hippocampal CA1 neurons.
Membrane propertyControlCholChol+Copper
Vm (mV)−66.5±0.71−68.1±1.03−60.2±3.07*
Input resistance (MΩ)72.87±6.9552.46±4.63*55.13±7.86
AP threshold (mV)−44.08±1.72−43.66±1.76−43.87±1.23
AP amplitude (mV)87.3±2.8989.24±2.9169.23±2.63¤¤¤
AP duration (ms)1.66±0.101.19±0.10**0.81±0.07***,¤
AP rising duration (ms)0.46±0.030.38±0.030.31±0.03***
AP falling duration (ms)1.09±0.10.81±0.08*0.5±0.05***,¤¤
AHP (mV)−5.14±1.04−2.31±0.79*−6.25±1.45¤
Latency (ms)69.85±14.057.96±14.6437.71±12.36
Current required for first elicited AP (nA)0.17±0.020.35±0.03***0.32±0.04***
Cell number (n) for Control, Chol, Chol+Copper was 25, 22, and 13, respectively. AP: Action potential; AP duration was measured at the width of 50% AP duration.*p<0.05 as compared to Control.**p<0.01 as compared to Control.***p<0.001 as compared to Control.¤p<0.05 as compared to Chol.¤¤p<0.01 as compared to Chol.¤¤¤p<0.001 as compared to Chol.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 72.87 ± 6.95 (25) 72.87 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -44.08 ± 1.72 (25) -44.08 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 87.3 ± 2.89 (25) 87.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.66 ± 0.1 (25) 1.66 (ms) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.46 ± 0.03 (25) 0.46 (ms) Data Table
Hippocampus CA1 pyramidal cell spike decay time (ms) 1.09 ± 0.1 (25) 1.09 (ms) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) -5.14 ± 1.04 (25) 5.14 (mV) Data Table
Hippocampus CA1 pyramidal cell first spike latency (ms) 69.85 ± 14.0 (25) 69.85 (ms) Data Table
Hippocampus CA1 pyramidal cell rheobase (nA) 0.17 ± 0.02 (25) 170.0 (pA) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -66.5 ± 0.71 (25) -66.5 (mV) Data Table