Article: Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lin YW; Min MY; Lin CC; Chen WN; Wu WL; Yu HM; Chen CC Neuroscience, 2008
Table 3Electrophysiological properties of four acid-sensitivity groups of lumbar DRG neurons (>34 μm)
Four acid-sensitivity groups exhibited distinct electrophysiological properties (cell size larger than 34 μm in diameter). SA, salicylic acid; SAS, salicylic acid sensitive; SART, salicylic acid resistant with transient acid-evoked current; SARS, salicylic acid resistant with sustained acid-evoked current; NAC, no acid-evoked current. Only among SAS neurons was the acid-evoked current sensitive to SA inhibition. The SAS neurons showed unique electrophysiological properties as compared with other groups. NA: nonapplicable.⁎P<0.05 compared with SAS values.⁎⁎P<0.01 compared with SAS values.
SAS (n=43) | SART (n=10) | SARS (n=53) | NAC (n=38) | |
Diameter (μm) | 40.0±0.6 | 40.0±1.5 | 41.2±0.7 | 40.6±0.7 |
Capacitance (pF) | 32.8±2.1 | 27.0±4.7 | 32.2±1.8 | 36.9±2.4 |
Vm (mV) | −56.5±1.0 | −55.8±2.0 | −54.5±1.1 | −51.8±1.4⁎⁎ |
AP (ms) | 6.0±0.3 | 6.3±0.9 | 4.8±0.3⁎ | 6.0±0.5 |
Half AP (ms) | 3.0±0.2 | 2.7±0.3 | 2.5±0.2 | 3.1±0.2 |
AP rise time (ms) | 2.3±0.1 | 2.3±0.3 | 2.0±0.1 | 2.3±0.1 |
AP fall time (ms) | 3.8±0.3 | 3.9±0.8 | 2.7±0.3⁎⁎ | 3.7±0.5 |
Overshoot (mV) | 47.9±4.3 | 51.1±7.6 | 35.7±3.1⁎ | 38.7±3.9⁎ |
AP threshold (pA) | 600.2±53.7 | 623.1±103.3 | 598.3±57.5 | 618.7±65.2 |
AHP (ms) | 183.0±19.0 | 153.4±38.8 | 110.9±15.3⁎⁎ | 120.4±6.7⁎⁎ |
Multiple spike (%) | 4.7 | 0 | 3.7 | 7.9 |
TTXr (%) | 27.9 | 18.1 | 22.6 | 36.8 |
Inflection (%) | 27.9 | 20.0 | 11.3 | 18.4 |
Capsaicin (%) | 39.5 | 18.8 | 26.4 | 0 |
IB4 (%) | 0 | 0 | 0 | 0 |
ASIC rising time (ms) | 55.5±3.7 | 68.7±8.1 | NA | NA |
Desensitization time (s) | 0.4±0.1 | 1.4±0.1⁎⁎ | NA | NA |
Inhibition by SA (%) | 40.8±3.6 | NA | NA | NA |
Peak amplitude (pA) | 977.6±131.5 | 296.7±49.7⁎⁎ | 112.3±15.9⁎⁎ | NA |
Current density (pQ) | 884.1±95.6 | 583.7±95.6 | 345.3±43.5⁎⁎ | NA |