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Article: Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3.

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Lin YW; Min MY; Lin CC; Chen WN; Wu WL; Yu HM; Chen CC
Neuroscience, 2008


Table 3Electrophysiological properties of four acid-sensitivity groups of lumbar DRG neurons (>34 μm)
SAS (n=43)SART (n=10)SARS (n=53)NAC (n=38)
Diameter (μm)40.0±0.640.0±1.541.2±0.740.6±0.7
Capacitance (pF)32.8±2.127.0±4.732.2±1.836.9±2.4
Vm (mV)−56.5±1.0−55.8±2.0−54.5±1.1−51.8±1.4⁎⁎
AP (ms)6.0±0.36.3±0.94.8±0.3⁎6.0±0.5
Half AP (ms)3.0±0.22.7±0.32.5±0.23.1±0.2
AP rise time (ms)2.3±0.12.3±0.32.0±0.12.3±0.1
AP fall time (ms)3.8±0.33.9±0.82.7±0.3⁎⁎3.7±0.5
Overshoot (mV)47.9±4.351.1±7.635.7±3.1⁎38.7±3.9⁎
AP threshold (pA)600.2±53.7623.1±103.3598.3±57.5618.7±65.2
AHP (ms)183.0±19.0153.4±38.8110.9±15.3⁎⁎120.4±6.7⁎⁎
Multiple spike (%)4.703.77.9
TTXr (%)27.918.122.636.8
Inflection (%)27.920.011.318.4
Capsaicin (%)39.518.826.40
IB4 (%)0000
ASIC rising time (ms)55.5±3.768.7±8.1NANA
Desensitization time (s)0.4±0.11.4±0.1⁎⁎NANA
Inhibition by SA (%)40.8±3.6NANANA
Peak amplitude (pA)977.6±131.5296.7±49.7⁎⁎112.3±15.9⁎⁎NA
Current density (pQ)884.1±95.6583.7±95.6345.3±43.5⁎⁎NA
Four acid-sensitivity groups exhibited distinct electrophysiological properties (cell size larger than 34 μm in diameter). SA, salicylic acid; SAS, salicylic acid sensitive; SART, salicylic acid resistant with transient acid-evoked current; SARS, salicylic acid resistant with sustained acid-evoked current; NAC, no acid-evoked current. Only among SAS neurons was the acid-evoked current sensitive to SA inhibition. The SAS neurons showed unique electrophysiological properties as compared with other groups. NA: nonapplicable.⁎P<0.05 compared with SAS values.⁎⁎P<0.01 compared with SAS values.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons cell diameter (μm) 40.6 ± 0.7 40.6 (um) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons cell capacitance (pF) 32.8 ± 2.1 32.8 (pF) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons cell capacitance (pF) 27.0 ± 4.7 27.0 (pF) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons cell capacitance (pF) 32.2 ± 1.8 32.2 (pF) Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons cell capacitance (pF) 36.9 ± 2.4 36.9 (pF) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons resting membrane potential (mV) -56.5 ± 1.0 -56.5 (mV) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons resting membrane potential (mV) -55.8 ± 2.0 -55.8 (mV) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons resting membrane potential (mV) -54.5 ± 1.1 -54.5 (mV) Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons resting membrane potential (mV) -51.8 ± 1.4 -51.8 (mV) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons spike width (ms) 6.0 ± 0.3 6.0 (ms) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons spike width (ms) 6.3 ± 0.9 6.3 (ms) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons spike width (ms) 4.8 ± 0.3 4.8 (ms) Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons spike width (ms) 6.0 ± 0.5 6.0 (ms) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons spike half-width (ms) 3.0 ± 0.2 3.0 (ms) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons spike half-width (ms) 2.7 ± 0.3 2.7 (ms) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons spike half-width (ms) 2.5 ± 0.2 2.5 (ms) Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons spike half-width (ms) 3.1 ± 0.2 3.1 (ms) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons spike peak (mV) 47.9 ± 4.3 47.9 (mV) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons spike peak (mV) 51.1 ± 7.6 51.1 (mV) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons spike peak (mV) 35.7 ± 3.1 35.7 (mV) Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons spike peak (mV) 38.7 ± 3.9 38.7 (mV) Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons spike threshold (pA) 600.2 ± 53.7 -- Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons spike threshold (pA) 623.1 ± 103.3 -- Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons spike threshold (pA) 598.3 ± 57.5 -- Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons spike threshold (pA) 618.7 ± 65.2 -- Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons AHP amplitude (ms) 183.0 ± 19.0 -- Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons AHP amplitude (ms) 153.4 ± 38.8 -- Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons AHP amplitude (ms) 110.9 ± 15.3 -- Data Table
Dorsal root ganglion cell No acid-evoked current lumbar root ganglion neurons AHP amplitude (ms) 120.4 ± 6.7 -- Data Table
Dorsal root ganglion cell Salicylic acid sensitive lumbar dorsal root ganglion neurons cell diameter (μm) 40.0 ± 0.6 40.0 (um) Data Table
Dorsal root ganglion cell Salicylic acid–resistant transient lumbar dorsal root ganglion neurons cell diameter (μm) 40.0 ± 1.5 40.0 (um) Data Table
Dorsal root ganglion cell Salicylic acid– resistant sustained lumbar dorsal root ganglion neurons cell diameter (μm) 41.2 ± 0.7 41.2 (um) Data Table