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Article: Modulation of action potential firing by iberiotoxin and NS1619 in rat dorsal root ganglion neurons.

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Zhang XF; Gopalakrishnan M; Shieh CC
Neuroscience, 2003


Table 2Effects of IbTx on passive electrical properties and action potentials in small and medium size neuronsa
RMP (mV)Threshold (mV)Duration (ms)Amplitude (mV)AHP (mV)
Small diameter neurons
Control−57.8±1.5 (5)−19.6±1.2 (5)5.4±0.6 (5)71.6±4.3 (5)44.0±1.9 (5)
IbTx−55.4±2.3 (5)−19.6±1.7 (5)7.0±1.0* (5)69.6±5.9 (5)44.0±2.3 (5)
Medium diameter neurons
Control−56.3±1.1 (9)−23.8±1.9 (9)5.1±0.7 (9)78.1±3.6 (9)35.1±2.2 (9)
IbTx−56.0±1.8 (9)−23.9±1.7 (9)8.7±2.1* (9)77.9±3.6 (9)34.9±1.8 (9)
aNumber of neurons tested is indicated in parentheses.*Indicates significant difference, P<0.05, Students' t-test.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell small dorsal root ganglion cell resting membrane potential (mV) -57.8 ± 1.5 (5) -57.8 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion cell spike threshold (mV) -19.6 ± 1.2 (5) -19.6 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion cell spike width (ms) 5.4 ± 0.6 (5) 5.4 (ms) Data Table
Dorsal root ganglion cell small dorsal root ganglion cell spike amplitude (mV) 71.6 ± 4.3 (5) 71.6 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion cell AHP amplitude (mV) 44.0 ± 1.9 (5) 44.0 (mV) Data Table
Dorsal root ganglion cell medium dorsal root ganglion cell resting membrane potential (mV) -56.3 ± 1.1 (9) -56.3 (mV) Data Table
Dorsal root ganglion cell medium dorsal root ganglion cell spike threshold (mV) -23.8 ± 1.9 (9) -23.8 (mV) Data Table
Dorsal root ganglion cell medium dorsal root ganglion cell spike width (ms) 5.1 ± 0.7 (9) 5.1 (ms) Data Table
Dorsal root ganglion cell medium dorsal root ganglion cell spike amplitude (mV) 78.1 ± 3.6 (9) 78.1 (mV) Data Table
Dorsal root ganglion cell medium dorsal root ganglion cell AHP amplitude (mV) 35.1 ± 2.2 (9) 35.1 (mV) Data Table