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Article: Chronic ethanol treatment alters AMPA-induced calcium signals in developing Purkinje neurons.

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Netzeband JG; Trotter C; Parsons KL; Gruol DL
Brain Res., 1999


Table 1Summary of effects of chronic ethanol treatment on the membrane response to AMPA at 15 DIV
DepolarizationHyperpolarization
Peak amplitude (mV)Duration (s)aPeak amplitude (mV)Duration (s)a
1 μM AMPA
Control (n=14)25±217±23±177±11
Chronic ethanol (n=17)26±218±13±0.576±7
5 μM AMPA
Control (n=16)33±248±47±1119±12
Chronic ethanol (n=19)34±153±47±1127±12
There was no difference between the control and chronic ethanol treatment groups for any of the measurements (P>0.05, unpaired t-test). All values are the mean±S.E.M. and represent combined data from studies performed in the presence and absence of TTX.aThe duration of the depolarization represents the time from AMPA application to recovery to baseline; the duration of the hyperpolarization is taken from the start of the hyperpolarization to when the hyperpolarization recovers to one-half of the maximal hyperpolarization.

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