Table 3Saturation parameters for the specific binding of [3H]MK801 in VH compared to DH as studied by the filter wipe-off technique
Region
Kd (nM)
Bmax (fmol/10 CA1 sections)
DH
Kd 5.5±0.2
Bmax 39×10−4±10−4
VH
Kd 4.1±0.4
Bmax 30×10−4±2×10−4 (*↓ 23%)
Data represent the means±S.E. of three independent binding experiments. In each experiment five animals were used for each preparation of the DH and VH. Statistically significant differences between VH and DH are indicated as * P<0.05 (paired t-test). Numbers in parentheses indicate the percentage of the lower levels.
