Article: Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.
Table 1Intrinsic properties of granule cells from epileptic human hippocampus
*Data are given as mean±M.D. *Statistically significant difference between type I and type II cells (α=0.05).††Only 21 neurons were averaged; see ‡.*‡Only 16 neurons were averaged. Three type I cells were excluded from this analysis because the number of APs evoked by the current pulse protocol fell out of range.*§0.47±0.15nA were injected, which depolarized the cells to −50±4mV.∥∥0.46±0.17nA were injected, which depolarized the cells to −46±3mV.
|Pooled (n=24)||Type I (n=19)||Type II (n=5)|
|Resting potential (mV)||−70±6||−71±6||−66±7|
|Input resistance (MΩ)||58±13||59±13||54±12|
|Time constant (ms)||12.1±2.8||11.9±3.0||13.0±1.9|
|AP amplitude (mV)||64±8||61±6||75±5*|
|AP duration (ms)||1.3±0.2||1.3±0.2||1.3±0.1|
|AP rise (V/s)||272±55||249±43||358±28*|
|AP decay (V/s)||−124±21||−120±22||−140±16|
|Fast AHP amplitude (mV)||10.4±3.1||11.2±2.6||7.2±3.3*|
|AHP 1/4 decay time (ms)||35±17||28±13||61±5*|
|Spike frequency adaptation||3.1±1.1†||2.6±0.8‡§||4.8±1.0*∥|