Table 1Passive and active membrane properties of hippocampal CA1 pyramidal neurons from HD and WT mice
Young WT
Young HD
Old WT
Old HD
Mean
S.E.
n
Mean
S.E.
n
Mean
S.E.
n
Mean
S.E.
n
Age (weeks)
11.65
±0.61
21
14
±1.76
12
99.67
±3.09
11
97.0
±2.53
18
RMP (mV)
−73.0
±1.78
21
−72.2
±2.20
12
−69.9
±2.093
11
−69.1
±2.61
18
Resistance (MΩ)
131.0
±8.79
21
173.4
±36.12
12
108.1
±16.68
11
128.0
±9.96
18
τ (ms)
20.62
±2.38
21
16.94
±3.32
12
15.14
±3.11
11
20.55
±3.11
18
AP threshold (mV)
−46.8
±2.43
15
−46.1
±4.1
5
−48.8
±1.81
7
−46.6
±1.63
12
Rheobase (nA)
0.05
±0.03
15
0.1
±0.03
5
0.04
±0.05
7
0.08
±0.03
12
AP amplitude (mV)
73.86
±2.62
15
66.78
±12.66
5
65.9
±7.06
7
73.4
±4.37
12
AP ½ amp dur (ms)
1.707
±0.08
15
2.5
±0.645
5
2.11
±0.48
7
1.78
±0.29
12
Max rise slope (mV/ms)
109.0
±7.53
15
87.38
±19.55
5
100.7
±27.78
7
106.1
±13.02
12
Max decay slope (mV/ms)
−45.6
±2.29
15
−34.9
±8.57
5
−43.6
±9.18
7
−47.7
±4.77
12
AHP amp (mV)
1.76
±0.29
15
2.08
±0.7
5
3.12
±0.78
7
3.86
±0.56
12
APs per 0.05 nA (n)
2.0
±0.61
20
0.9
±0.67
10
3.0
±1.5
10
1.86
±1.03
14
APs per 0.1 nA (n)
5.15
±1.13
20
5.3
±1.56
10
3.2
±1.96
10
4.71
±1.52
14
APs per 0.4 nA (n)
9.15
±1.83
20
9.7
±3.11
10
7.7
±3.37
10
9.29
±2.49
14
Shortest spike interval (ms)
16.85
±2.91
16
13.87
±1.14
6
6.15
±2.6
6
17.0
±2.64
12
1st to last spike interval ratio
22.91
±2.49
13
30.17
±3.40
6
20.75
±8.66
4
24.78
±5.11
9
Summary table showing pooled data following electrophysiological characterisation of CA1 pyramidal cells from young adult and aged HD mice and age-matched WT controls. Data from the stated number of cells (n) are presented as mean±standard error (S.E.). Abbreviations of electrical properties are as in Fig. 1 and for details of parameter measurements see Experimental procedures.
