Article: Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Graves AR; Moore SJ; Bloss EB; Mensh BD; Kath WL; Spruston N Neuron, 2012
Table 1Properties of Hippocampal Pyramidal Cells
Mean ± SEM for all values. Electrophysiology, n = 268; morphology, n = 110.
Regular Spiking | Bursting | p Value | |
Electrophysiology | |||
RN | 55.0 ± 3.1 MΩ | 33.7 ± 2.0 MΩ | <0.001 |
Sag ratio | 0.84 ± 0.02 | 0.74 ± 0.02 | <0.001 |
Subthreshold dV/dt | 2.61mV/ms ± 0.53mV/ms | 4.39mV/ms ± 0.49mV/ms | <0.001 |
ADP amplitude | 17.9mV ± 1.3mV | 22.2mV ± 0.9mV | <0.001 |
Second spike threshold | −40.8mV ± 0.7mV | −45.1mV ± 0.9mV | <0.001 |
Max second falling dV/dt | −56mV/ms ± 3mV/ms | −65mV/ms ± 3mV/ms | <0.01 |
Max second rising dV/dt | 240mV/ms ± 24mV/ms | 272mV/ms ± 22mV/ms | <0.05 |
First spike FWHM | 0.87 ± 0.01 ms | 0.82 ± 0.02 ms | <0.05 |
Resting membrane potential | −65.8mV ± 0.7mV | −66.2mV ± 0.4mV | n.s. |
First spike threshold | −53.1mV ± 1.0mV | −52.4mV ± 0.6mV | n.s. |
Max first spike rising dV/dt | 460mV/ms ± 21mV/ms | 488mV/ms ± 21mV/ms | n.s. |
Max first spike falling dV/dt | −106mV/ms ± 4mV/ms | −113mV/ms ± 5mV/ms | n.s. |
Second spike FWHM | 1.18 ± 0.03 ms | 1.14 ± 0.04 ms | n.s. |
First spike height | 92.0mV ± 1.5mV | 90.3mV ± 1.6mV | n.s. |
Second spike height | 71.3mV ± 3.0mV | 70.0mV ± 2.3mV | n.s. |
AHP amplitude | −1.29mV ± 0.25mV | −1.39mV ± 0.31mV | n.s. |
Morphology | |||
Total tuft dendrite length | 1.39 ± 0.02 mm | 1.49 ± 0.03 mm | <0.01 |
Total basal dendrite length | 3.89 ± 0.26 mm | 3.08 ± 0.17 mm | <0.01 |
Basal branching order | 4.40 ± 0.26 | 3.29 ± 0.23 | <0.01 |
Distance to main bifurcation | 193.8 ± 19.3 μm | 264.4 ± 22.8 μm | <0.05 |
Basal branch points | 50.1 ± 3.8 | 40.9 ± 3.1 | <0.05 |
Tuft branch points | 33.7 ± 2.8 | 41.6 ± 3.3 | <0.05 |
Apical branching order | 4.91 ± 0.72 | 7.93 ± 1.48 | <0.05 |
Proximal apical dendrite length | 1.76 ± 0.21 mm | 1.35 ± 0.14 mm | n.s. |
Middle apical dendrite length | 1.67 ± 0.28 mm | 1.48 ± 0.16 mm | n.s. |
Proximal apical branching order | 5.53 ± 0.47 | 4.98 ± 0.36 | n.s. |
Middle apical branching order | 4.81 ± 0.32 | 4.16 ± 0.40 | n.s. |
Proximal apical branch points | 25.0 ± 3.4 | 28.0 ± 2.6 | n.s. |
Middle apical branch points | 33.7 ± 1.9 | 34.6 ± 3.2 | n.s. |
Basal branches off soma | 3.90 ± 0.47 | 3.65 ± 0.39 | n.s. |