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Article: GABAergic synaptic inhibition is reduced before seizure onset in a genetic model of cortical malformation.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Trotter SA; Kapur J; Anzivino MJ; Lee KS J. Neurosci., 2006
Table 1.
Membrane and action potential properties in layer V pyramidal neurons of the neocortex
| Control | Normotopic | Heterotopic | |
|---|---|---|---|
| Membrane properties | |||
| RMP (mV) | −61.5 ± 0.5 (n = 20) | −57.9 ± 0.6** (n = 7) | −56.2 ± 0.9** (n = 6) |
| RN (MΩ) | 56.0 ± 2.3 (n = 28) | 66.5 ± 7.2 (n = 13) | 65.8 ± 5.9 (n = 12) |
| CM (pF) | 0.94 ± 0.06 (n = 21) | 0.86 ± 0.09 (n = 29) | 0.90 ± 0.06 (n = 35) |
| sIPSCs | |||
| Frequency (Hz) | 4.00 ± 0.56 | 2.21 ± 0.42* | 2.53 ± 0.43* |
| Amplitude (pA) | 71.9 ± 9.3 | 47.0 ± 3.0* | 59.9 ± 4.3 |
| n | 13 | 16 | 14 |
| mIPSCs | |||
| Frequency (Hz) | 2.45 ± 0.34 | 1.60 ± 0.23* | 1.54 ± 0.28* |
| Amplitude (pA) | 43.6 ± 2.5 | 42.5 ± 2.2 | 45.6 ± 3.1 |
| n | 13 | 16 | 16 |
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | input resistance (MΩ) | 56.0 ± 2.3 | 56.0 (MΩ) | Data Table |
| Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | cell capacitance (pF) | 0.94 ± 0.06 | -- | Data Table |
| Neocortex pyramidal cell layer 5-6 | Neocortex layer 5 pyramidal neuron | resting membrane potential (mV) | -61.5 ± 0.5 | -61.5 (mV) | Data Table |