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Article: Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Yoshimura N; Bennett NE; Hayashi Y; Ogawa T; Nishizawa O; Chancellor MB; de Groat WC; Seki S
J. Neurosci., 2006


Table 2.

Membrane characteristics of bladder afferent neurons in vehicle-treated and NGF-treated rats

Vehicle NGF
1 week 2 week
Neurons with TTX-resistant spikes
    No. of cells 30 34 42
    Diameter (μm) 24.1 ± 1.6 26.8 ± 1.4 29.9 ± 1.5*
    Input capacitance (pF) 30.4 ± 1.6 34.1 ± 2.5 42.8 ± 3.4**
    RMP (mV) −54.5 ± 2.3 −54.0 ± 2.1 −53.5 ± 1.8
    Spike threshold (mV) −21.1 ± 1.1 −25.4 ± 1.6* −28.1 ± 1.7**
    Spike duration (ms) 8.1 ± 0.5 7.51 ± 0.6 6.9 ± 0.4
    No. of spikes (600 ms depolarization) 1.3 ± 0.2 7.7 ± 2.2* 11.6 ± 1.8**
    Capsaicin sensitivity 28/30 (93%) 32/34 (94%) 39/42 (93%)
Neurons with TTX-sensitive spikes
    No. of cells 12 13 16
    Diameter (μm) 34.1 ± 1.7** 35.2 ± 1.5 35.8 ± 1.3
    Input capacitance (pF) 47.2 ± 2.2** 46.2 ± 2.8 47.9 ± 2.6
    RMP (mV) −57.2 ± 2.9 −58.0 ± 2.1 −56.9 ± 2.6
    Spike threshold (mV) −29.3 ± 1.5** −29.8 ± 1.7 −30.1 ± 1.6
    Spike duration (ms) 5.2 ± 0.7* 5.0 ± 0.5 5.1 ± 0.6
    No. of spikes (600 ms depolarization) 11.3 ± 2.1** 12.2 ± 1.6 12.3 ± 1.8
    Capsaicin sensitivity 1/12 (8%) 1/13 (8%) 2/16 (12%)
  • RMP, Resting membrane potential.

  • *p < 0.05,

  • **p < 0.01 compared with the value in bladder afferent neurons with TTX-resistant spikes from vehicle-treated rats.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell cell diameter (μm) 24.1 ± 1.6 24.1 (um) Data Table
Dorsal root ganglion cell cell capacitance (pF) 30.4 ± 1.6 30.4 (pF) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -54.5 ± 2.3 -54.5 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -21.1 ± 1.1 -21.1 (mV) Data Table
Dorsal root ganglion cell spike width (ms) 8.1 ± 0.5 8.1 (ms) Data Table
Dorsal root ganglion cell cell diameter (μm) 34.1 ± 1.7 34.1 (um) Data Table
Dorsal root ganglion cell cell capacitance (pF) 47.2 ± 2.2 47.2 (pF) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -57.2 ± 2.9 -57.2 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -29.3 ± 1.5 -29.3 (mV) Data Table
Dorsal root ganglion cell spike width (ms) 5.2 ± 0.7 5.2 (ms) Data Table