Article: Modulation of neuronal excitability by serotonin-NMDA interactions in prefrontal cortex.
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Zhong P; Yuen EY; Yan Z
Mol. Cell. Neurosci., 2008
Table 1Membrane properties of PFC pyramidal neurons treated with different drugs
| ACSF | NMDA | NMDA+DPAT |
| Resting Potential (mV) | −71.6±2.1 | −68.3±2.5 | −70.1±3.5 |
| Spike Threshold (mV) | −52.3±2.6 | −51.8±2.2 | −52.1±4.1 |
| Input Resistance (M?) | 133.7±22.4 | 150.5±34.6 | 146.4±39.3 |
| Max AHP (mV) | 6.5±0.8 | 5.4±0.6 | 6.2±0.7 |
| Spike Amplitude (mV) | 79.3±3.2 | 78.8±4.0 | 78.5±5.2 |
| Spike Halfwidth (ms) | 2.0±0.2 | 2.1±0.2 | 2.1±0.3 |
| Latency to 1st spike (ms) | 71.1±3.9 | 41.8±3.1 | 60.2±3.4* |
| Rheobase (pA) | 121.7±5.6 | 76.6±5.1 | 105.0±5.8* |
| NMDA | NMDA+α-Me-5HT |
| Resting Potential (mV) | −68.7±2.7 | −66.8±3.2 |
| Spike Threshold (mV) | −51.6±2.1 | −51.9±3.3 |
| Input Resistance (MΩ) | 148.5±33.5 | 158.1±37.8 |
| Max AHP (mV) | 5.5±1.2 | 4.1±1.3 |
| Spike Amplitude (mV) | 78.7±3.9 | 78.1±4.7 |
| Spike Halfwidth (ms) | 2.1±0.2 | 2.1±0.3 |
| Latency to 1st spike (ms) | 43.4±3.8 | 30.4±2.1* |
| Rheobase (pA) | 74.8±4.8 | 53.6±5.2* |
Values are expressed as mean±SEM. *: p<0.05, ANOVA, compared with control (NMDA alone), n=5–6 per group.
Inferred neuron-electrophysiology data values
