Table 1Electrophysiological parameters of pyramidal neurons recorded from WT and Lis1/sLis1 animals
P7
P30
WT
Lis1/sLis1
WT
Lis1/sLis1
Resting potential (mV)
−60.6±2.5 (−52 −70) n=44
−66.4±2.9 (−52 −69) n=29
−65.4±2.4 (−54 −88) n=39
−66.1±3.5 (−64 −75) n=27
Input resistance (MΩ)
467±50.1 (88–1900) n=44
614±73.9 (191–1700) n=29
156±12.1 (47–399) n=39
165±17.9 (52–526) n=27
a.p. amplitude (mV)
66.2±1.7 (54.7–81.2) n=23
68.7±2.3 (55.4–78.9) n=11
78.4±1.5 (54.4–89.2) n=25
80.0±1.9 (67.1–99.7) n=22
a.p. duration (ms)
1.77±0.87 (1.22–2.38) n=23
1.66±0.13 (0.99–2.33) n=11
1.02±0.06 (0.57–2.14) n=25
0.86±0.04⁎ (0.47–1.15) n=22
Ahp amplitude (mV)
17.0±1.27 (6.2–29.3) n=23
15.5±1.33 (7.35–22.1) n=11
12.6±1.70 (4.6–23.3) n=25
15.4±1.78 (8.5–22.8) n=22
Action potential (a.p.) amplitude was measured with respect to the threshold potential, and action potential duration was measured at half amplitude. Input resistance was measured from the voltage deflection produced by small hyperpolarizing current pulses (e.g. Fig. 1) and the amplitude of the after-hyperpolarization (Ahp) was measured from the threshold level to the most negative peak. Input resistance was calculated from responses to small hyperpolarizing current pulses. The mean±s.e.m., the range (in parenthesis), and the number of observations are provided for each parameter.⁎p<0.05 compared with P30, WT.
