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Article: A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

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Otto JF; Yang Y; Frankel WN; White HS; Wilcox KS
J. Neurosci., 2006


Table 2.

IK(M) amplitude and density values are reduced across a range of voltage steps in Szt1 CA1 neurons

Step from −20 mV IK(M) amplitude (pA) IK(M) density (pA/pF)
B6 Szt1 B6 Szt1
−50 mV 53.3 ± 4.6 (12) 42.3 ± 2.0* (13) 0.46 ± 0.03 0.38 ± 0.02*
−60 mV 33.9 ± 2.4 (34) 23.2 ± 1.2* (28) 0.29 ± 0.02 0.21 ± 0.01*
−70 mV 13.0 ± 3.0 (12) 5.8 ± 1.7* (12) 0.12 ± 0.02 0.05 ± 0.02*

  • IK(M) amplitude values were measured at various potentials in response to hyperpolarizing steps from −20 to −50, −60, and −70 mV. In response to all three hyperpolarizing return steps, Szt1 CA1 neurons exhibited significantly decreased IK(M) amplitude relative to that of B6 mice. Szt1 CA1 neurons also show a significantly decreased IK(M) density at the same hyperpolarizing return steps (

  • ↵*p < 0.05, ANOVA). Current densities were calculated by dividing the IK(M) amplitude of each cell by its capacitance. The numbers of cells recorded from (in parentheses) are identical for IK(M) amplitude and density values within the same genotype.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source