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Article: Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures.

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McCloskey DP; Croll SD; Scharfman HE
J. Neurosci., 2005


Table 1.

Comparison of intrinsic properties of CA1 pyramidal cells before and after VEGF bath application

n Control VEGF
Membrane properties
    RMP (mV) 10 -62.0 ± 1.3 -61.9 ± 1.3
    RIN (MΩ) 9 42.9 ± 5.2 47.9 ± 5.1
    τ(ms) 9 11.0 ± 1.9 8.5 ± 1.2
Action potential amplitude
    Total (mV) 8 77.6 ± 1.9 72.7 ± 3.4
    From threshold (mV) 8 68.7 ± 2.1 66.6 ± 2.8
Action potential slope
    Maximum rise (V/s) 8 362.5 ± 39.3 342.5 ± 45.6
    Maximum decay (V/s) 8 80.7 ± 14.6 71.4 ± 13.1
    dv/dt ratio 8 5.3 ± 0.7 5.9 ± 0.9
Action potential duration
    Total (ms) 8 2.9 ± 0.7 2.6 ± 0.4
    Half-duration (ms) 8 0.76 ± 0.3 0.44 ± 0.1
  • Measurement of intrinsic properties showed no significant changes after bath application of VEGF. Measurements were made after at least 30 min of exposure to VEGF, at a time when synaptic potentials were maximally depressed (mean ± SEM; paired Student's t test, p > 0.05). RMP, Resting membrane potential; RIN, input resistance; τ, time constant; dv/dt ratio, ratio of the maximal slope of the rising phase/maximal slope of the decay phase.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 42.9 ± 5.2 (8) 42.9 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 11.0 ± 1.9 (8) 11.0 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 68.7 ± 2.1 (8) 68.7 (mV) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope (V/s) 362.5 ± 39.3 (8) 362.5 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike max decay slope (V/s) 80.7 ± 14.6 (8) 80.7 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike width (ms) 2.9 ± 0.7 (8) 2.9 (ms) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 0.76 ± 0.3 (8) 0.76 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -62.0 ± 1.3 (8) -62.0 (mV) Data Table