Article: Hearing loss raises excitability in the auditory cortex.
|Group||Resting potential (mV)||Input resistance (MΩ)||Half-spike width (ms)||Threshold current to elicit spike (pA)||Spike threshold (ΔVm in mV)|
|Normal adapting (n = 11)||−64±2.2||265±26||1.8±0.18||58±5||22±1.5|
|SNHL adapting (n = 10)||−61±1.4||410±29||2.2±0.19||36±2||16±1.4|
|SNHL sustained (n = 6)||−59.8±1.4||375±17||2.4±0.37||20±3.6||12.8±1.7|
Statistical comparisons of membrane properties of ∼100 recorded neurons appear in Figure 1 and Results. Properties of a subset adapting and sustained neurons were additionally compared (columns 1, 2). Furthermore, ∼25% of neurons from each group (left column) were blindly selected to compare the half-spike width, spike thresholds (in picoamperes, subthreshold current injected before the cell spiked and the resultant Vm). Statistical analyses: half-spike width (not different) among the three groups, one-way ANOVA, p = 0.22, df = 26; spike thresholds (in picoamperes), normal adapting versus SNHL adapting, t test, t = 3.4, df = 20, p < 0.002; SNHL adapting versus SNHL sustained, t test, t = 3.5, df = 15, p < 0.003; spike threshold (Vm: the difference between the VREST and spike threshold); normal adapting versus SNHL adapting, t test, t = 2.6, df = 20, p< 0.01; SNHL adapting versus SNHL sustained (not different), p = 0.19. For frequency-intensity (F-I) correlation coefficients, see Results and Figure 1E.
Inferred neuron-electrophysiology data values
|Neuron Type||Neuron Description||Ephys Prop||Extracted Value||Standardized Value||Content Source|
|Other||Primary Auditory Cortex Layers 2/3 Pyramidal Neurons||resting membrane potential (mV)||-64.0 ± 2.2 (11)||-64.0 (mV)||Data Table|
|Other||Primary Auditory Cortex Layers 2/3 Pyramidal Neurons||input resistance (MΩ)||265.0 ± 26.0 (11)||265.0 (MΩ)||Data Table|
|Other||Primary Auditory Cortex Layers 2/3 Pyramidal Neurons||spike half-width (ms)||1.8 ± 0.18 (11)||1.8 (ms)||Data Table|
|Other||Primary Auditory Cortex Layers 2/3 Pyramidal Neurons||rheobase (pA)||58.0 ± 5.0 (11)||58.0 (pA)||Data Table|
|Other||Primary Auditory Cortex Layers 2/3 Pyramidal Neurons||other||22.0 ± 1.5 (11)||22.0 (None)||Data Table|