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Article: Hearing loss raises excitability in the auditory cortex.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Kotak VC; Fujisawa S; Lee FA; Karthikeyan O; Aoki C; Sanes DH J. Neurosci., 2005
Membrane properties of adapting and sustained firing neurons
| Group | Resting potential (mV) | Input resistance (MΩ) | Half-spike width (ms) | Threshold current to elicit spike (pA) | Spike threshold (ΔVm in mV) |
|---|---|---|---|---|---|
| Normal adapting (n = 11) | −64±2.2 | 265±26 | 1.8±0.18 | 58±5 | 22±1.5 |
| SNHL adapting (n = 10) | −61±1.4 | 410±29 | 2.2±0.19 | 36±2 | 16±1.4 |
| SNHL sustained (n = 6) | −59.8±1.4 | 375±17 | 2.4±0.37 | 20±3.6 | 12.8±1.7 |
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Statistical comparisons of membrane properties of ∼100 recorded neurons appear in Figure 1 and Results. Properties of a subset adapting and sustained neurons were additionally compared (columns 1, 2). Furthermore, ∼25% of neurons from each group (left column) were blindly selected to compare the half-spike width, spike thresholds (in picoamperes, subthreshold current injected before the cell spiked and the resultant Vm). Statistical analyses: half-spike width (not different) among the three groups, one-way ANOVA, p = 0.22, df = 26; spike thresholds (in picoamperes), normal adapting versus SNHL adapting, t test, t = 3.4, df = 20, p < 0.002; SNHL adapting versus SNHL sustained, t test, t = 3.5, df = 15, p < 0.003; spike threshold (Vm: the difference between the VREST and spike threshold); normal adapting versus SNHL adapting, t test, t = 2.6, df = 20, p< 0.01; SNHL adapting versus SNHL sustained (not different), p = 0.19. For frequency-intensity (F-I) correlation coefficients, see Results and Figure 1E.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Other | Primary Auditory Cortex Layers 2/3 Pyramidal Neurons | resting membrane potential (mV) | -64.0 ± 2.2 (11) | -64.0 (mV) | Data Table |
| Other | Primary Auditory Cortex Layers 2/3 Pyramidal Neurons | input resistance (MΩ) | 265.0 ± 26.0 (11) | 265.0 (MΩ) | Data Table |
| Other | Primary Auditory Cortex Layers 2/3 Pyramidal Neurons | spike half-width (ms) | 1.8 ± 0.18 (11) | 1.8 (ms) | Data Table |
| Other | Primary Auditory Cortex Layers 2/3 Pyramidal Neurons | rheobase (pA) | 58.0 ± 5.0 (11) | 58.0 (pA) | Data Table |
| Other | Primary Auditory Cortex Layers 2/3 Pyramidal Neurons | other | 22.0 ± 1.5 (11) | 22.0 (None) | Data Table |