Article: Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Swensen AM; Bean BP J. Neurosci., 2005
Nav1.6+/+ (n = 19) | Nav1.6−/− (n = 16) | t test results | |
---|---|---|---|
Action potential peak | +41 ± 3 mV | +32 ± 7 mV | p < 0.001** |
Interspike voltage | −68 ± 4 mV | −64 ± 4 mV | p = 0.01* |
Interspike interval | 6.4 ± 3.2 ms | 8.4 ± 2.8 ms | p = 0.07 |
Action potential threshold | −53 ± 3 mV | −43 ± 3 mV | p < 0.002** |
Action potential width (at 0 mV) | 0.41 ± 0.07 ms | 0.43 ± 0.06 ms | p = 0.589 |
Afterhyperpolarization | −74 ± 2 mV | −70 ± 4 mV | p = 0.003* |
Afterdepolarization | −68 ± 3 mV | −62 ± 5 mV | p < 0.001** |
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The action potential peak was measured for the first spike of the burst. The interspike voltage was averaged over a 1.3 ms time window starting 1.5 ms after the peak of the first action potential. The interspike interval was measured between the peaks of the first and second spikes. The action potential threshold was defined as the voltage at which dV/dt exceeded 20 mV/ms (measured for the first action potential), and action potential width was defined as the width at 0 mV. The afterhyperpolarization was the most negative voltage reached after the first spike, and the afterdepolarization was the most positive voltage reached after the last spike. *p ≤ 0.01; **p < 0.002.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Cerebellum Purkinje cell | spike threshold | -53.0 ± 3.0 | -53.0 (mV) | Data Table | |
Cerebellum Purkinje cell | spike half-width | 0.41 ± 0.07 | 0.41 (ms) | Data Table | |
Cerebellum Purkinje cell | spike peak | 41.0 ± 3.0 | 41.0 (mV) | Data Table | |
Cerebellum Purkinje cell | AHP voltage | -74.0 ± 2.0 | -74.0 (mV) | Data Table |