Article: Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies.
Table 2Pharmacological responses of 5-HT-containing and non-5-HT-containing cells in the rat DRN
5-HT-IR+
5-HT-IR−
Silent cells
5-CT elicited hyperpolarization (mV)
8.1±1.6 (14)
8.7±1.8 (15)
PE elicited depolarization (mV)
9.0±2.1 (5)
9.3±1.9 (7)
PE elicited firing rate (Hz)
0.4±0.2 (5)
0.2±0.1 (7)
5-CT elicited hyperpolarization of PE-stimulated cells (mV)
11.7±3.8 (3)
8.4±2.0 (5)
5-CT effect on PE-stimulated firing rate: % change
all cells silenced: −100%±0.0 (3)
all cells silenced: −100%±0.0 (3)
Spontaneously active cells
5-CT elicited hyperpolarization (mV)
11.0±1.4 (3)
1.4±1.1** (5)
5-CT effect on firing rate: % change
all cells silenced: −100%±0.0 (3)
no cells silenced: −36.0±17.5* (5)
Values indicate mean±S.E.M. The group size is indicated within parentheses. Asterisks indicate a significant difference between groups by unpaired Student’s t-test (P<0.05*; P<0.001**). These distinguishing characteristics are further highlighted by bold print.
