Article: KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Bourdeau ML; Laplante I; Laurent CE; Lacaille JC Neuroscience, 2011
Table 1Similar action potential waveform and broadening in transfected interneurons in slice cultures
aHolding potential: −74 mV; cells submitted to 1-s, +200 pA current injections.bProperties of the first action potentials induced. Statistical analysis indicated no significant difference (P>0.05).cHalf-width values normalized to AP #1. Statistical analysis indicated no significant difference (P>0.05).
YFP/siRNA-CTL(n=6) | YFP/siRNA-KChIP1(n=6) | |
Action potential waveforma,b | ||
Threshold (mV) | −66.9±1.9 | −66.0±1.3 |
Amplitude (mV) | 99.0±3.7 | 93.0±3.8 |
Half-width duration (ms) | 2.30±0.22 | 1.91±0.14 |
AHP amplitude (mV) | 10.6±2.8 | 13.9±0.7 |
Action potential broadeninga,c | ||
AP #2 (relative half-width) | 1.19±0.04 | 1.39±0.11 |
AP #3 (relative half-width) | 1.28±0.06 | 1.60±0.20 |
AP #4 (relative half-width) | 1.35±0.08 | 1.74±0.25 |
AP #5 (relative half-width) | 1.37±0.08 | 1.84±0.30 |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Hippocampus CA1 oriens lacunosum moleculare neuron | Hippocampus CA1 oriens lacunosum moleculare interneuron | spike half-width (ms) | 2.3 ± 0.22 (6) | 2.3 (ms) | Data Table |
Hippocampus CA1 oriens lacunosum moleculare neuron | Hippocampus CA1 oriens lacunosum moleculare interneuron | AHP amplitude (mV) | 10.6 ± 2.8 (6) | 10.6 (mV) | Data Table |
Hippocampus CA1 oriens lacunosum moleculare neuron | Hippocampus CA1 oriens lacunosum moleculare interneuron | spike threshold (mV) | -66.9 ± 1.9 (6) | -66.9 (mV) | Data Table |
Hippocampus CA1 oriens lacunosum moleculare neuron | Hippocampus CA1 oriens lacunosum moleculare interneuron | spike amplitude (mV) | 99.0 ± 3.7 (6) | 99.0 (mV) | Data Table |