Property | Cluster 2 (C2, n = 45) | Cluster 3 (C3, n = 55) | Cluster 2 L6 (C2 L6, n = 173) | Cluster 3 L6 (C3 L6, n = 53) | ||
---|---|---|---|---|---|---|
Input resistance, MΩ | 390.7 ± 159.5 | 375.0 ± 109.4 | 429.9 ± 142.8 | 374.6 ± 111.3 | ||
C2 –C3 | C2 L6 –C3 L6 | |||||
Sag, membrane resistance decrease, % | 13.8 ± 5.6 | 9.6 ± 6.5 | 11.8 ± 4.7 | 9.4 ± 6.5 | ||
C2 ≫ C3 | C2 L6 > C3 L6 | |||||
First spike amplitude, mV | 82.9 ± 7.0 | 93.6 ± 6.8 | 82.8 ± 8.8 | 93.8 ± 6.8 | ||
C3 ≫ C2 | C3 L6 ≫ C2 L6 | |||||
Second spike amplitude, mV | 76.9 ± 7.6 | 91.1 ± 7.2 | 75.6 ± 9.5 | 91.4 ± 7.2 | ||
C3 ≫ C2 | C3 L6 ≫ C2 L6 | |||||
Amplitude reduction, % | 7.1 ± 6.0 | 2.6 ± 2.3 | 8.7 ± 5.8 | 2.6 ± 2.2 | ||
C2 ≫ C3 | C2 L6 ≫ C3 L6 | |||||
First spike duration, ms | 1.5 ± 0.3 | 2.0 ± 0.4 | 1.7 ± 0.2 | 2.0 ± 0.4 | ||
C3 ≫ C2 | C3 L6 ≫ C2 L6 | |||||
Second spike duration, ms | 1.9 ± 0.5 | 2.3 ± 0.5 | 2.2 ± 0.4 | 2.3 ± 0.5 | ||
C3 ≫ C2 | C2 L6 –C3 L6 | |||||
Duration increase, % | 27.9 ± 15.9 | 12.4 ± 7.7 | 24.3 ± 16.5 | 12.4 ± 7.7 | ||
C2 ≫ C3 | C2 L6 ≫ C3 L6 | |||||
First AHP, mV | −8.4 ± 3.7 | −14.5 ± 3.3 | −9.4 ± 3.8 | −14.6 ± 3.3 | ||
C3 ≫ C2 | C3 L6 ≫ C2 L6 | |||||
Second AHP, mV | −13.6 ± 3.2 | −15.1 ± 3.3 | −15.5 ± 3.3 | −15.1 ± 3.4 | ||
C3 > C2 | C2 L6 –C3 L6 | |||||
Early adaptation, % | 62.1 ± 13.0 | 43.9 ± 7.0 | 60.9 ± 14.7 | 44.0 ± 6.9 | ||
C2 ≫ C3 | C2 L6 ≫ C3 L6 | |||||
Late adaptation, % | 17.5 ± 12.8 | 19.4 ± 7.6 | 11.5 ± 11.9 | 19.6 ± 7.6 | ||
C2 –C3 | C3 L6 > C2 L6 |
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Values are means ± SD; n is the number of cells; > significantly greater with P ≤ 0.005; ≫ significantly greater with P ≤ 0.001; –not significantly different. Statistically significant differences were determined using the Mann–Whitney U test. Electrophysiological parameters were measured as described in methods. Cluster 2 L6 and cluster 3 L6 correspond to layer VI neurons from clusters 2 and 3, respectively.