Article: Prostaglandin E2 depresses solitary tract-mediated synaptic transmission in the nucleus tractus solitarius.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Laaris N; Weinreich D Neuroscience, 2007
Table 1Effect of PGE2 on the passive and active membrane properties
Overshoot measured from 0 mV to peak depolarization of the AP. Afterhyperpolarization (AHP) measured from the resting membrane potential to the maximal membrane hypepolarization. AP duration measured at one-half peak amplitude. The membrane Rin shows a significant decrease (* P<0.05, paired t-test) after PGE2 treatment. The apparent increase in the rheobase after PGE2 treatment was not significantly different (P>0.05, paired t-test) owing to variability in the data set; 6 of the 10 NTS neurons showed no change. CTR denotes control; PGE2 bath applied at 100 nM. Numbers in parentheses are number of neurons tested.⁎P<0.05.
Treatment | AP overshoot (mV) | AP AHP (mV) | AP duration (ms) | AP threshold (mV) | Rheobase (pA) | Number AP at 2x rheobase | Rin (MΩ) |
CTR | 64±3.3(n=11) | −6±2.2(n=11) | 1.1±0.1(n=11) | −25±2(n=11) | 44±15(n=10) | 13.3±2.2(n=12) | 540±46.1(n=12) |
PGE2 | 67±4.4(n=11) | −7±2.1(n=11) | 1.2±0.1(n=11) | −27±2(n=11) | 82±26(n=10) | 17.9±3.3(n=12) | 346±46.0⁎(n=12) |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | spike peak (mV) | 64.0 ± 3.3 (11) | 64.0 (mV) | Data Table |
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | AHP amplitude from resting (mV) | -6.0 ± 2.2 (11) | 6.0 (mV) | Data Table |
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | spike width (ms) | 1.1 ± 0.1 (11) | 1.1 (ms) | Data Table |
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | spike threshold (mV) | -25.0 ± 2.0 (11) | -25.0 (mV) | Data Table |
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | rheobase (pA) | 44.0 ± 15.0 (10) | 44.0 (pA) | Data Table |
Nucleus of the solitary tract intrinsic cell | Nucleus Tractus Solitarius Neurons | input resistance (MΩ) | 540.0 ± 46.1 (12) | 540.0 (MΩ) | Data Table |