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Article: The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons.

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Pérez-Garci E; Gassmann M; Bettler B; Larkum ME
Neuron, 2006


Table 1Electrophysiological Properties of L5 Pyramidal Neurons in Wild-Type and GABAB1-Isoform Knockout Mice
RMP (mV)RN (MΩ)Rheobase (pA)CF (Hz)ADP (mV)
Wild-type (n = 48)65.7 ± 0.637.0 ± 1.4339.6 ± 15.7104.7 ± 5.58.0 ± 0.4
GABAB1a−/− (n = 14)64.5 ± 0.641.7 ± 3.4300.0 ± 25.7104.2 ± 10.47.1 ± 0.5
GABAB1b−/− (n = 17)63.9 ± 0.538.8 ± 3.4323.5 ± 20.2115.5 ± 9.07.3 ± 0.8
RMP, resting membrane potential; RN, input resistance; Rheobase, threshold current for AP; CF, critical frequencies; ADP, afterdepolarizing potential at a supracritical frequency.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5 pyramidal GABAergic neurons rheobase (pA) 339.6 ± 15.7 (48) 339.6 (pA) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5 pyramidal GABAergic neurons ADP amplitude (mV) 8.0 ± 0.4 (48) 8.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5 pyramidal GABAergic neurons resting membrane potential (mV) 65.7 ± 0.6 (48) -65.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 somatosensory cortex layer 5 pyramidal GABAergic neurons input resistance (MΩ) 37.0 ± 1.4 (48) 37.0 (MΩ) Data Table